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Open Access
Peer-reviewed
Research Article
The molecular and metabolic program by which white adipocytes adapt to cool physiologic temperatures
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Hiroyuki Mori ,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft
* E-mail: morimori@umich.edu (HM); macdouga@umich.edu (OAM)
Affiliation Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
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Colleen E. Dugan,
Roles Formal analysis, Investigation, Methodology
Affiliation Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
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Akira Nishii,
Roles Formal analysis, Investigation, Methodology
Affiliation Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
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Ameena Benchamana,
Roles Investigation
Affiliation Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
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Ziru Li,
Roles Investigation
Affiliation Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
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Thomas S. Cadenhead IV,
Roles Investigation
Affiliation Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
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Arun K. Das,
Roles Formal analysis, Investigation, Methodology
Affiliation Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
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Charles R. Evans,
Roles Investigation, Methodology
Affiliation Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
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Katherine A. Overmyer,
Roles Formal analysis, Investigation, Project administration
Affiliations Morgridge Institute for Research, Madison, Wisconsin, United States of America, National Center for Quantitative Biology of Complex Systems, Madison, Wisconsin, United States of America
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Steven M. Romanelli,
Roles Investigation
Affiliation Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
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Sydney K. Peterson,
Roles Investigation
Affiliation Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
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Devika P. Bagchi,
Roles Investigation
Affiliation Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
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Callie A. Corsa,
Roles Investigation
Affiliation Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
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Julie Hardij,
Roles Investigation
Affiliation Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
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Brian S. Learman,
Roles Investigation
Affiliation Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
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Mahmoud El Azzouny,
Roles Funding acquisition
Affiliation Agilent Technologies, Inc., Santa Clara, California, United States of America
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Joshua J. Coon,
Roles Investigation, Supervision
Affiliations Morgridge Institute for Research, Madison, Wisconsin, United States of America, National Center for Quantitative Biology of Complex Systems, Madison, Wisconsin, United States of America, Department of Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin, United States of America, Department of Chemistry, University of Wisconsin, Madison, Wisconsin, United States of America
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Ken Inoki,
Roles Supervision
Affiliations Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America
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Ormond A. MacDougald
Roles Conceptualization, Funding acquisition, Project administration, Resources, Writing – review & editing
* E-mail: morimori@umich.edu (HM); macdouga@umich.edu (OAM)
Affiliations Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
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The molecular and metabolic program by which white adipocytes adapt to cool physiologic temperatures
- Hiroyuki Mori,
- Colleen E. Dugan,
- Akira Nishii,
- Ameena Benchamana,
- Ziru Li,
- Thomas S. Cadenhead IV,
- Arun K. Das,
- Charles R. Evans,
- Katherine A. Overmyer,
- Steven M. Romanelli
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- Published: May 12, 2021
- https://doi.org/10.1371/journal.pbio.3000988