A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19

• Yadi Zhou ,

  Contributed equally to this work with: Yadi Zhou, Yuan Hou

  Roles Formal analysis, Investigation, Methodology, Software, Validation, Writing – original draft

  Affiliation Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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• Yuan Hou ,

  Contributed equally to this work with: Yadi Zhou, Yuan Hou

  Roles Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Affiliation Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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• Jiayu Shen,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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• Reena Mehra,

  Roles Validation

  Affiliations Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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• Asha Kallianpur,

  Roles Validation

  Affiliations Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Daniel A. Culver,

  Roles Validation

  Affiliations Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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• Michaela U. Gack,

  Roles Validation

  Affiliation Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, Florida, United States of America

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• Samar Farha,

  Roles Validation

  Affiliations Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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• Joe Zein,

  Roles Validation

  Affiliations Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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• Suzy Comhair,

  Roles Validation

  Affiliations Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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• Claudio Fiocchi,

  Roles Validation

  Affiliations Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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• Thaddeus Stappenbeck,

  Roles Validation

  Affiliations Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

  https://orcid.org/0000-0002-6023-3901

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• Timothy Chan,

  Roles Validation

  Affiliations Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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• Charis Eng,

  Roles Validation

  Affiliations Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

  https://orcid.org/0000-0002-3693-5145

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• Jae U. Jung,

  Roles Validation

  Affiliations Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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• Lara Jehi,

  Roles Resources, Validation

  Affiliations Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

  https://orcid.org/0000-0002-8041-6377

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• Serpil Erzurum,

  Roles Resources, Validation, Writing – review & editing

  Affiliations Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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•  [ ... ],
• Feixiong Cheng

  Roles Conceptualization, Funding acquisition, Investigation, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: chengf@ccf.org

  Affiliations Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

  https://orcid.org/0000-0002-1736-2847

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