Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia

Laura Bousset; Amandine Septier; Julio Bunay; Allison Voisin; Rachel Guiton; Christelle Damon-Soubeyrant; Yoan Renaud; Angélique De Haze; Vincent Sapin; Anne Fogli; Amandine Rambur; Cyrille De Joussineau; Ayhan Kocer; Amalia Trousson; Joëlle Henry-Berger; Marcus Höring; Gerhard Liebisch; Silke Matysik; Jean-Marc A. Lobaccaro; Laurent Morel; Silvère Baron

doi:10.1371/journal.pbio.3000948

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Open Access

Peer-reviewed

Research Article

Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia

Laura Bousset,

Roles Conceptualization, Investigation, Writing – original draft

Affiliations Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, Clermont-Ferrand, France, Centre de Recherche en Nutrition Humaine d’Auvergne, Clermont-Ferrand, France

https://orcid.org/0000-0002-5339-3173

⨯
Amandine Septier,

Roles Data curation, Formal analysis, Investigation, Software

Affiliations Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, Clermont-Ferrand, France, Centre de Recherche en Nutrition Humaine d’Auvergne, Clermont-Ferrand, France

https://orcid.org/0000-0002-5431-7439

⨯
Julio Bunay,

Roles Investigation

Affiliations Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, Clermont-Ferrand, France, Centre de Recherche en Nutrition Humaine d’Auvergne, Clermont-Ferrand, France

https://orcid.org/0000-0002-1953-952X

⨯
Allison Voisin,

Roles Investigation

Affiliation Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, Clermont-Ferrand, France
⨯
Rachel Guiton,

Roles Investigation

Affiliation Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, Clermont-Ferrand, France
⨯
Christelle Damon-Soubeyrant,

Affiliation Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, Clermont-Ferrand, France
⨯
Yoan Renaud,

Affiliation Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, Clermont-Ferrand, France
⨯
Angélique De Haze,

Affiliation Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, Clermont-Ferrand, France
⨯
Vincent Sapin,

Roles Resources

Affiliation Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, Clermont-Ferrand, France

https://orcid.org/0000-0002-7452-315X

⨯
Anne Fogli,

Roles Investigation

Affiliation Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, Clermont-Ferrand, France
⨯
Amandine Rambur,

Roles Investigation

Affiliations Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, Clermont-Ferrand, France, Centre de Recherche en Nutrition Humaine d’Auvergne, Clermont-Ferrand, France
⨯
Cyrille De Joussineau,

Roles Investigation

Affiliations Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, Clermont-Ferrand, France, Centre de Recherche en Nutrition Humaine d’Auvergne, Clermont-Ferrand, France

https://orcid.org/0000-0002-2488-2760

⨯
Ayhan Kocer,

Affiliations Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, Clermont-Ferrand, France, Centre de Recherche en Nutrition Humaine d’Auvergne, Clermont-Ferrand, France
⨯
Amalia Trousson,

Roles Investigation

Affiliations Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, Clermont-Ferrand, France, Centre de Recherche en Nutrition Humaine d’Auvergne, Clermont-Ferrand, France

https://orcid.org/0000-0001-6587-9501

⨯
Joëlle Henry-Berger,

Affiliation Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, Clermont-Ferrand, France
⨯
Marcus Höring,

Affiliation Institute of Clinical Chemistry and Laboratory Medicine, Regensburg University Hospital, Regensburg, Germany

https://orcid.org/0000-0002-3651-392X

⨯
Gerhard Liebisch,

Affiliation Institute of Clinical Chemistry and Laboratory Medicine, Regensburg University Hospital, Regensburg, Germany

https://orcid.org/0000-0003-4886-0811

⨯
Silke Matysik,

Affiliation Institute of Clinical Chemistry and Laboratory Medicine, Regensburg University Hospital, Regensburg, Germany
⨯
Jean-Marc A. Lobaccaro,

Roles Conceptualization, Investigation, Methodology, Supervision, Writing – original draft

Affiliations Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, Clermont-Ferrand, France, Centre de Recherche en Nutrition Humaine d’Auvergne, Clermont-Ferrand, France

https://orcid.org/0000-0001-9890-2392

⨯
Laurent Morel,

Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing – original draft

Affiliations Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, Clermont-Ferrand, France, Centre de Recherche en Nutrition Humaine d’Auvergne, Clermont-Ferrand, France

https://orcid.org/0000-0003-0005-1919

⨯
[ ... ],
Silvère Baron

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft

* E-mail: silvere.baron@uca.fr

Affiliations Université Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103, Clermont-Ferrand, France, Centre de Recherche en Nutrition Humaine d’Auvergne, Clermont-Ferrand, France

https://orcid.org/0000-0002-4524-3087

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Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia

Laura Bousset,
Amandine Septier,
Julio Bunay,
Allison Voisin,
Rachel Guiton,
Christelle Damon-Soubeyrant,
Yoan Renaud,
Angélique De Haze,
Vincent Sapin,
Anne Fogli

Published: December 7, 2020
https://doi.org/10.1371/journal.pbio.3000948

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Prostate gland
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Prostate cancer
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Inflammation
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Castration
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Macrophages
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Androgens
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