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Open Access
Peer-reviewed
Research Article
Structural myelin defects are associated with low axonal ATP levels but rapid recovery from energy deprivation in a mouse model of spastic paraplegia
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Andrea Trevisiol ,
Contributed equally to this work with: Andrea Trevisiol, Kathrin Kusch
Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliation Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany
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Kathrin Kusch ,
Contributed equally to this work with: Andrea Trevisiol, Kathrin Kusch
Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing
Affiliation Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany
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Anna M. Steyer,
Roles Investigation, Methodology, Visualization
Affiliations Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany, Electron Microscopy Core Facility, Max Planck Institute of Experimental Medicine, Göttingen, Germany
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Ingo Gregor,
Roles Methodology, Resources
Affiliation Third Institute of Physics, Georg August University, Göttingen, Germany
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Christos Nardis,
Roles Formal analysis, Methodology
Affiliations Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany, Electron Microscopy Core Facility, Max Planck Institute of Experimental Medicine, Göttingen, Germany
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Ulrike Winkler,
Roles Formal analysis, Methodology
Affiliation Carl Ludwig Institute for Physiology, Faculty of Medicine, University of Leipzig, Leipzig, Germany
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Susanne Köhler,
Roles Formal analysis, Investigation, Methodology
Affiliation Carl Ludwig Institute for Physiology, Faculty of Medicine, University of Leipzig, Leipzig, Germany
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Alejandro Restrepo,
Roles Formal analysis, Investigation
Affiliation Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany
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Wiebke Möbius,
Roles Investigation, Methodology, Visualization
Affiliations Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany, Electron Microscopy Core Facility, Max Planck Institute of Experimental Medicine, Göttingen, Germany
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Hauke B. Werner,
Roles Writing – original draft, Writing – review & editing
Affiliation Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany
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Klaus-Armin Nave ,
Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing
* E-mail: nave@em.mpg.de (KAN); johannes.hirrlinger@medizin.uni-leipzig.de, hirrlinger@em.mpg.de (JH)
Affiliation Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany
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Johannes Hirrlinger
Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing
* E-mail: nave@em.mpg.de (KAN); johannes.hirrlinger@medizin.uni-leipzig.de, hirrlinger@em.mpg.de (JH)
Affiliations Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany, Carl Ludwig Institute for Physiology, Faculty of Medicine, University of Leipzig, Leipzig, Germany
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Structural myelin defects are associated with low axonal ATP levels but rapid recovery from energy deprivation in a mouse model of spastic paraplegia
- Andrea Trevisiol,
- Kathrin Kusch,
- Anna M. Steyer,
- Ingo Gregor,
- Christos Nardis,
- Ulrike Winkler,
- Susanne Köhler,
- Alejandro Restrepo,
- Wiebke Möbius,
- Hauke B. Werner
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- Published: November 16, 2020
- https://doi.org/10.1371/journal.pbio.3000943