YAP/TAZ deficiency reprograms macrophage phenotype and improves infarct healing and cardiac function after myocardial infarction

Masum M. Mia; Dasan Mary Cibi; Siti Aishah Binte Abdul Ghani; Weihua Song; Nicole Tee; Sujoy Ghosh; Junhao Mao; Eric N. Olson; Manvendra K. Singh

doi:10.1371/journal.pbio.3000941

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Open Access

Peer-reviewed

Research Article

YAP/TAZ deficiency reprograms macrophage phenotype and improves infarct healing and cardiac function after myocardial infarction

Masum M. Mia,

Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – original draft

Affiliation Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School Singapore. Singapore
⨯
Dasan Mary Cibi,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School Singapore. Singapore
⨯
Siti Aishah Binte Abdul Ghani,

Roles Data curation, Formal analysis, Methodology, Validation, Visualization

Affiliation Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School Singapore. Singapore

https://orcid.org/0000-0003-2317-0179

⨯
Weihua Song,

Roles Data curation, Methodology, Validation

Affiliation National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore
⨯
Nicole Tee,

Roles Data curation, Formal analysis, Methodology, Validation

Affiliation National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore
⨯
Sujoy Ghosh,

Roles Data curation, Formal analysis, Methodology, Software

Affiliation Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School Singapore. Singapore
⨯
Junhao Mao,

Roles Resources

Affiliation Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Eric N. Olson,

Roles Resources

Affiliation Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
⨯
Manvendra K. Singh

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: manvendra.singh@duke-nus.edu.sg

Affiliations Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School Singapore. Singapore, National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore

https://orcid.org/0000-0002-2884-0074

⨯

YAP/TAZ deficiency reprograms macrophage phenotype and improves infarct healing and cardiac function after myocardial infarction

Masum M. Mia,
Dasan Mary Cibi,
Siti Aishah Binte Abdul Ghani,
Weihua Song,
Nicole Tee,
Sujoy Ghosh,
Junhao Mao,
Eric N. Olson,
Manvendra K. Singh

Published: December 2, 2020
https://doi.org/10.1371/journal.pbio.3000941

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Heart
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