NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype

• Mahmoud H. Elbatreek ,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: melbatreek@ppmlab.net (MHE); hschmidt@ppmlab.net (HHHWS)

  Affiliations Department of Pharmacology and Personalised Medicine, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands, Department of Pharmacology and Toxicology, School of Pharmacy, Zagazig University, Zagazig, Egypt

  https://orcid.org/0000-0003-2437-1773

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• Sepideh Sadegh,

  Roles Data curation, Formal analysis, Methodology, Software

  Affiliation Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany

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• Elisa Anastasi,

  Roles Formal analysis, Methodology, Software

  Affiliation School of Computing, Newcastle University, Newcastle, United Kingdom

  https://orcid.org/0000-0002-8701-2295

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• Emre Guney,

  Roles Conceptualization, Methodology, Software, Writing – review & editing

  Affiliations Department of Pharmacology and Personalised Medicine, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands, Research Programme on Biomedical Informatics, The Hospital del Mar Medical Research Institute and Pompeu Fabra University, Barcelona, Spain

  https://orcid.org/0000-0002-3466-6535

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• Cristian Nogales,

  Roles Methodology, Software, Visualization

  Affiliation Department of Pharmacology and Personalised Medicine, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands

  https://orcid.org/0000-0001-7535-0417

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• Tim Kacprowski,

  Roles Data curation, Formal analysis, Methodology, Software, Writing – review & editing

  Affiliations Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany, Division of Data Science in Biomedicine, Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School, Brunswick, Germany

  https://orcid.org/0000-0002-5393-2413

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• Ahmed A. Hassan,

  Roles Data curation, Formal analysis, Methodology, Software, Writing – review & editing

  Affiliation Department of Pharmacology and Personalised Medicine, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands

  https://orcid.org/0000-0002-9725-2794

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• Andreas Teubner,

  Roles Writing – review & editing

  Affiliation Central Animal Facility, CPV, Maastricht University, Maastricht, the Netherlands

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• Po-Hsun Huang,

  Roles Formal analysis, Methodology, Resources, Validation

  Affiliations Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, Department of Critical Care Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

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• Chien-Yi Hsu,

  Roles Formal analysis, Methodology, Resources, Validation

  Affiliations Division of Cardiology and Cardiovascular Research Center, Taipei Medical University Hospital, Taipei, Taiwan, Taipei Heart Institute, Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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• Paul M. H. Schiffers,

  Roles Methodology, Resources

  Affiliation Department of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands

  https://orcid.org/0000-0002-4963-7219

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• Ger M. Janssen,

  Roles Methodology, Resources

  Affiliation Department of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands

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• Pamela W. M. Kleikers,

  Roles Formal analysis, Methodology

  Affiliation Department of Pharmacology and Personalised Medicine, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands

  ⨯
• Anil Wipat,

  Roles Investigation, Software

  Affiliation School of Computing, Newcastle University, Newcastle, United Kingdom

  https://orcid.org/0000-0001-7310-4191

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• Jan Baumbach,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliations Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany, Department of Mathematics and Computer Science, University of Southern Denmark, Odense, Denmark

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• Jo G. R. De Mey,

  Roles Conceptualization, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Pharmacology and Personalised Medicine, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands

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•  [ ... ],
• Harald H. H. W. Schmidt

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: melbatreek@ppmlab.net (MHE); hschmidt@ppmlab.net (HHHWS)

  Affiliation Department of Pharmacology and Personalised Medicine, School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, the Netherlands

  https://orcid.org/0000-0003-0419-5549

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