Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits

• André T. Lopes ,

  Contributed equally to this work with: André T. Lopes, Torben J. Hausrat

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  http://orcid.org/0000-0001-9920-5556

  ⨯
• Torben J. Hausrat ,

  Contributed equally to this work with: André T. Lopes, Torben J. Hausrat

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  ⨯
• Frank F. Heisler,

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliation Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  ⨯
• Kira V. Gromova,

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliation Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  http://orcid.org/0000-0002-5956-0673

  ⨯
• Franco L. Lombino,

  Roles Formal analysis, Investigation, Software, Visualization, Writing – review & editing

  Affiliation Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  http://orcid.org/0000-0003-2326-6920

  ⨯
• Timo Fischer,

  Roles Formal analysis, Investigation, Software

  Affiliation Division of Neurophysiology, University of Hamburg, Hamburg, Germany

  http://orcid.org/0000-0002-4431-5931

  ⨯
• Laura Ruschkies,

  Roles Formal analysis, Investigation, Visualization

  Affiliation Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  ⨯
• Petra Breiden,

  Roles Formal analysis, Investigation

  Affiliation Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  ⨯
• Edda Thies,

  Roles Formal analysis, Investigation, Visualization

  Affiliation Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  http://orcid.org/0000-0002-3753-5274

  ⨯
• Irm Hermans-Borgmeyer,

  Roles Conceptualization, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

  Affiliation Transgenic Animal Unit, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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• Michaela Schweizer,

  Roles Conceptualization, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

  Affiliation Morphology Unit, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  ⨯
• Jürgen R. Schwarz,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – review & editing

  Affiliation Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  http://orcid.org/0000-0002-4141-6972

  ⨯
• Christian Lohr,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing – review & editing

  Affiliation Division of Neurophysiology, University of Hamburg, Hamburg, Germany

  http://orcid.org/0000-0001-6518-6422

  ⨯
• Matthias Kneussel

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: matthias.kneussel@zmnh.uni-hamburg.de

  Affiliation Department of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  http://orcid.org/0000-0003-4900-366X

  ⨯