Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection

• Hitoshi Tsugawa ,

  Roles Data curation, Formal analysis, Investigation

  * E-mail: h.tsugawa@keio.jp (HT); ykabe@keio.jp (YK); gasbiology@keio.jp (MS)

  ¶‡ These authors share first authorship on this work.

  Affiliation Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan

  http://orcid.org/0000-0002-4344-4475

  ⨯
• Yasuaki Kabe ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: h.tsugawa@keio.jp (HT); ykabe@keio.jp (YK); gasbiology@keio.jp (MS)

  ¶‡ These authors share first authorship on this work.

  Affiliations Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan, Japan Agency for Medical Research and Development (AMED), Core Research for Evolutional Science and Technology (CREST), Tokyo, Japan

  http://orcid.org/0000-0003-0952-011X

  ⨯
• Ayaka Kanai,

  Roles Formal analysis

  Affiliation Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan

  ⨯
• Yuki Sugiura,

  Roles Data curation, Formal analysis

  Affiliation Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan

  ⨯
• Shigeaki Hida,

  Roles Funding acquisition

  Affiliation Department of Molecular and Cellular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan

  ⨯
• Shun’ichiro Taniguchi,

  Roles Formal analysis

  Affiliation Department of Comprehensive Cancer Therapy, Shinshu University School Medicine, Matsumoto, Japan

  ⨯
• Toshio Takahashi,

  Roles Formal analysis

  Affiliation Suntory Foundation for Life Sciences, Bioorganic Research Institute, Kyoto, Japan

  http://orcid.org/0000-0002-1822-0939

  ⨯
• Hidenori Matsui,

  Roles Formal analysis, Methodology

  Affiliation Omura Satoshi Memorial Institute, Kitasato University, Tokyo, Japan

  ⨯
• Zenta Yasukawa,

  Roles Resources

  Affiliation TAIYO KAGAKU CO., LTD., Mie, Japan

  ⨯
• Hiroyuki Itou,

  Roles Resources

  Affiliation Meiji Co., Ltd., Tokyo, Japan

  ⨯
• Keiyo Takubo,

  Roles Data curation, Formal analysis

  Affiliation Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

  ⨯
• Hidekazu Suzuki,

  Roles Conceptualization

  Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan

  http://orcid.org/0000-0002-8994-6163

  ⨯
• Kenya Honda,

  Roles Formal analysis, Resources

  Affiliation Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan

  http://orcid.org/0000-0001-8937-9835

  ⨯
• Hiroshi Handa,

  Roles Methodology, Writing – original draft

  Affiliation Department of Chemical Biology, Tokyo Medical University, Tokyo, Japan

  http://orcid.org/0000-0001-6656-9521

  ⨯
• Makoto Suematsu

  Roles Conceptualization, Writing – original draft

  * E-mail: h.tsugawa@keio.jp (HT); ykabe@keio.jp (YK); gasbiology@keio.jp (MS)

  Affiliation Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan

  http://orcid.org/0000-0002-7165-6336

  ⨯