Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex

• Xuxiao He ,

  Contributed equally to this work with: Xuxiao He, Min Li

  Roles Conceptualization, Investigation, Methodology, Writing – original draft

  Affiliations CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences (CAS), Shanghai, China, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China

  ⨯
• Min Li ,

  Contributed equally to this work with: Xuxiao He, Min Li

  Roles Investigation, Methodology

  Affiliations CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences (CAS), Shanghai, China, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China

  ⨯
• Hongming Yu,

  Roles Investigation, Resources

  Affiliation The Eastern Hepatobiliary Surgery Hospital, Shanghai, China

  ⨯
• Guijun Liu,

  Roles Investigation

  Affiliations CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences (CAS), Shanghai, China, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China

  ⨯
• Ningning Wang,

  Roles Investigation

  Affiliations CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences (CAS), Shanghai, China, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China

  ⨯
• Chunzhao Yin,

  Roles Investigation

  Affiliations University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China, School of Life Science and Technology, ShanghaiTech University, Shanghai, China

  ⨯
• Qiaochu Tu,

  Roles Investigation

  Affiliations University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China, School of Life Science and Technology, ShanghaiTech University, Shanghai, China

  ⨯
• Goutham Narla,

  Roles Resources, Writing – review & editing

  Affiliation Division of Genetic Medicine, Department of International Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

  https://orcid.org/0000-0003-4098-4203

  ⨯
• Yongzhen Tao ,

  Roles Funding acquisition, Supervision

  * E-mail: yztao01@sibs.ac.cn (YT); chengshuqun@aliyun.com(SC); hyyin@sibs.ac.cn (HY)

  Affiliation CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences (CAS), Shanghai, China

  ⨯
• Shuqun Cheng ,

  Roles Resources, Supervision

  * E-mail: yztao01@sibs.ac.cn (YT); chengshuqun@aliyun.com(SC); hyyin@sibs.ac.cn (HY)

  Affiliation The Eastern Hepatobiliary Surgery Hospital, Shanghai, China

  ⨯
• Huiyong Yin

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Validation, Writing – review & editing

  * E-mail: yztao01@sibs.ac.cn (YT); chengshuqun@aliyun.com(SC); hyyin@sibs.ac.cn (HY)

  ¶‡ Lead contact.

  Affiliations CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences (CAS), Shanghai, China, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China, School of Life Science and Technology, ShanghaiTech University, Shanghai, China, Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China

  https://orcid.org/0000-0001-7049-1560

  ⨯