An in vitro model of tumor heterogeneity resolves genetic, epigenetic, and stochastic sources of cell state variability

• Corey E. Hayford,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Chemical and Physical Biology Graduate Program, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Darren R. Tyson,

  Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

  Affiliation Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

  https://orcid.org/0000-0002-3272-4308

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• C. Jack Robbins III,

  Roles Data curation, Formal analysis, Investigation

  Current address: MD-PhD Graduate Program, Yale University School of Medicine, New Haven, Connecticut, United States of America

  Affiliation Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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• Peter L. Frick,

  Roles Data curation, Methodology

  Current address: Intuit Inc., Mountain View, California, United States of America

  Affiliation Chemical and Physical Biology Graduate Program, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

  https://orcid.org/0000-0003-0236-5911

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• Vito Quaranta,

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

  https://orcid.org/0000-0001-7491-8672

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• Leonard A. Harris

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: harrisl@uark.edu

  Affiliations Department of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas, United States of America, Interdisciplinary Graduate Program in Cell and Molecular Biology, University of Arkansas, Fayetteville, Arkansas, United States of America, Cancer Biology Program, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

  https://orcid.org/0000-0003-2112-6940

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