Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis

• Marcos Sterkel ,

  Contributed equally to this work with: Marcos Sterkel, Lee R. Haines

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  * E-mail: msterkel@conicet.gov.ar (MS); laith.yakob@lshtm.ac.uk (LY); alvaro.acosta-serrano@lstmed.ac.uk (AAS)

  Affiliation Centro Regional de Estudios Genómicos, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina

  https://orcid.org/0000-0002-2266-9616

  ⨯
• Lee R. Haines ,

  Contributed equally to this work with: Marcos Sterkel, Lee R. Haines

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Department of Vector Biology, Liverpool School of Tropical Medicine, United Kingdom

  ⨯
• Aitor Casas-Sánchez,

  Roles Data curation, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Department of Vector Biology, Liverpool School of Tropical Medicine, United Kingdom

  https://orcid.org/0000-0001-5237-1223

  ⨯
• Vincent Owino Adung’a,

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – review & editing

  Affiliations International Centre of Insect Physiology and Ecology, Nairobi, Kenya, Department of Biochemistry and Molecular Biology, Egerton University, Kenya

  https://orcid.org/0000-0003-2802-690X

  ⨯
• Raquel J. Vionette-Amaral,

  Roles Data curation, Investigation, Validation, Writing – review & editing

  Affiliation Department of Vector Biology, Liverpool School of Tropical Medicine, United Kingdom

  ⨯
• Shannon Quek,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, United Kingdom

  https://orcid.org/0000-0002-1583-9541

  ⨯
• Clair Rose,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Department of Vector Biology, Liverpool School of Tropical Medicine, United Kingdom

  https://orcid.org/0000-0001-7782-5359

  ⨯
• Mariana Silva dos Santos,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Crick Institute, London, United Kingdom

  https://orcid.org/0000-0003-2404-8490

  ⨯
• Natalia García Escude,

  Roles Data curation, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Department of Vector Biology, Liverpool School of Tropical Medicine, United Kingdom

  https://orcid.org/0000-0002-8808-1532

  ⨯
• Hanafy M. Ismail,

  Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Department of Vector Biology, Liverpool School of Tropical Medicine, United Kingdom

  https://orcid.org/0000-0002-9953-9588

  ⨯
• Mark I. Paine,

  Roles Data curation, Formal analysis, Investigation, Supervision, Validation, Writing – review & editing

  Affiliation Department of Vector Biology, Liverpool School of Tropical Medicine, United Kingdom

  https://orcid.org/0000-0003-2061-7713

  ⨯
• Seth M. Barribeau,

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – review & editing

  Affiliation Department of Ecology Evolution & Behaviour, Institute of Integrative Biology, University of Liverpool, United Kingdom

  ⨯
• Simon Wagstaff,

  Roles Data curation, Methodology, Supervision, Validation, Writing – review & editing

  Affiliation Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, United Kingdom

  https://orcid.org/0000-0003-0577-5537

  ⨯
• James I. MacRae,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Crick Institute, London, United Kingdom

  https://orcid.org/0000-0002-1464-8583

  ⨯
• Daniel Masiga,

  Roles Data curation, Investigation, Supervision, Validation, Writing – review & editing

  Affiliation International Centre of Insect Physiology and Ecology, Nairobi, Kenya

  https://orcid.org/0000-0001-7513-0887

  ⨯
• Laith Yakob ,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  * E-mail: msterkel@conicet.gov.ar (MS); laith.yakob@lshtm.ac.uk (LY); alvaro.acosta-serrano@lstmed.ac.uk (AAS)

  Affiliation Department of Disease Control, London School of Hygiene and Tropical Medicine, United Kingdom

  https://orcid.org/0000-0001-8639-4511

  ⨯
• Pedro L. Oliveira,

  Roles Conceptualization, Data curation, Supervision, Validation, Visualization, Writing – review & editing

  Affiliations Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular (INCT-EM), Rio de Janeiro, Brazil

  https://orcid.org/0000-0003-0307-354X

  ⨯
•  [ ... ],
• Álvaro Acosta-Serrano

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: msterkel@conicet.gov.ar (MS); laith.yakob@lshtm.ac.uk (LY); alvaro.acosta-serrano@lstmed.ac.uk (AAS)

  Affiliations Department of Vector Biology, Liverpool School of Tropical Medicine, United Kingdom, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, United Kingdom

  https://orcid.org/0000-0002-2576-7959

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