Cell–substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime

Shashi Prakash Singh; Peter A. Thomason; Sergio Lilla; Matthias Schaks; Qing Tang; Bruce L. Goode; Laura M. Machesky; Klemens Rottner; Robert H. Insall

doi:10.1371/journal.pbio.3000774

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Open Access

Peer-reviewed

Research Article

Cell–substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime

Shashi Prakash Singh,

Roles Conceptualization, Data curation, Investigation, Methodology, Validation, Writing – original draft

Affiliation CRUK Beatson Institute, Glasgow, United Kingdom
⨯
Peter A. Thomason,

Roles Conceptualization

Affiliation CRUK Beatson Institute, Glasgow, United Kingdom

http://orcid.org/0000-0003-3104-8392

⨯
Sergio Lilla,

Roles Methodology

Affiliation CRUK Beatson Institute, Glasgow, United Kingdom

http://orcid.org/0000-0003-3142-7640

⨯
Matthias Schaks,

Roles Methodology, Resources

Affiliation Zoological Institute, Technische Universität Braunschweig, Braunschweig, Germany & Cell Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany

http://orcid.org/0000-0001-6362-7909

⨯
Qing Tang,

Roles Methodology

Affiliation Brandeis University, Waltham, Massachusetts, United States of America
⨯
Bruce L. Goode,

Roles Resources, Writing – review & editing

Affiliation Brandeis University, Waltham, Massachusetts, United States of America

http://orcid.org/0000-0002-6443-5893

⨯
Laura M. Machesky,

Roles Conceptualization, Writing – review & editing

Affiliation CRUK Beatson Institute, Glasgow, United Kingdom

http://orcid.org/0000-0002-7592-9856

⨯
Klemens Rottner,

Roles Methodology, Resources

Affiliation Zoological Institute, Technische Universität Braunschweig, Braunschweig, Germany & Cell Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany

http://orcid.org/0000-0003-4244-4198

⨯
Robert H. Insall

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: Robert.Insall@glasgow.ac.uk

Affiliations CRUK Beatson Institute, Glasgow, United Kingdom, Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom

http://orcid.org/0000-0003-4898-040X

⨯

Cell–substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime

Shashi Prakash Singh,
Peter A. Thomason,
Sergio Lilla,
Matthias Schaks,
Qing Tang,
Bruce L. Goode,
Laura M. Machesky,
Klemens Rottner,
Robert H. Insall

Published: August 3, 2020
https://doi.org/10.1371/journal.pbio.3000774

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