Metabolic excretion associated with nutrient–growth dysregulation promotes the rapid evolution of an overt metabolic defect

• Robin Green ,

  Contributed equally to this work with: Robin Green, Sonal

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Validation, Visualization

  * E-mail: robingreen525@gmail.com (RG); wenying.shou@gmail.com (WS)

  Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  http://orcid.org/0000-0001-7411-0593

  ⨯
• Sonal ,

  Contributed equally to this work with: Robin Green, Sonal

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – review & editing

  Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  http://orcid.org/0000-0002-2361-4131

  ⨯
• Lin Wang,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

  http://orcid.org/0000-0002-9370-6891

  ⨯
• Samuel F. M. Hart,

  Roles Data curation, Investigation, Validation, Visualization, Writing – review & editing

  Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  http://orcid.org/0000-0002-5068-2199

  ⨯
• Wenyun Lu,

  Roles Data curation, Investigation, Validation, Writing – review & editing

  Affiliation Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

  ⨯
• David Skelding,

  Roles Resources

  Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  ⨯
• Justin C. Burton,

  Roles Resources

  Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  http://orcid.org/0000-0002-4797-8968

  ⨯
• Hanbing Mi,

  Roles Investigation

  Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  ⨯
• Aric Capel,

  Roles Investigation

  Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  http://orcid.org/0000-0002-2748-379X

  ⨯
• Hung Alex Chen,

  Roles Investigation

  Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  http://orcid.org/0000-0001-5119-6208

  ⨯
• Aaron Lin,

  Roles Investigation

  Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  http://orcid.org/0000-0002-6006-0908

  ⨯
• Arvind R. Subramaniam,

  Roles Conceptualization, Writing – review & editing

  Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  ⨯
• Joshua D. Rabinowitz,

  Roles Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

  http://orcid.org/0000-0002-1247-4727

  ⨯
• Wenying Shou

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: robingreen525@gmail.com (RG); wenying.shou@gmail.com (WS)

  Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  http://orcid.org/0000-0001-5693-381X

  ⨯