Rab5c-mediated endocytic trafficking regulates hematopoietic stem and progenitor cell development via Notch and AKT signaling

Jian Heng; Peng Lv; Yifan Zhang; Xinjie Cheng; Lu Wang; Dongyuan Ma; Feng Liu

doi:10.1371/journal.pbio.3000696

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Open Access

Peer-reviewed

Research Article

Rab5c-mediated endocytic trafficking regulates hematopoietic stem and progenitor cell development via Notch and AKT signaling

Jian Heng,

Roles Conceptualization, Investigation, Writing – original draft

Affiliations State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Peng Lv,

Roles Investigation

Affiliations State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Yifan Zhang,

Roles Investigation

Affiliations State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Xinjie Cheng,

Roles Investigation

Affiliation State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

http://orcid.org/0000-0002-1208-9757

⨯
Lu Wang,

Roles Investigation

Affiliation State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

http://orcid.org/0000-0003-4788-3237

⨯
Dongyuan Ma,

Roles Investigation

Affiliations State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China

http://orcid.org/0000-0002-9710-5970

⨯
Feng Liu

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: liuf@ioz.ac.cn

Affiliations State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China

http://orcid.org/0000-0003-3228-0943

⨯

Rab5c-mediated endocytic trafficking regulates hematopoietic stem and progenitor cell development via Notch and AKT signaling

Jian Heng,
Peng Lv,
Yifan Zhang,
Xinjie Cheng,
Lu Wang,
Dongyuan Ma,
Feng Liu

Published: April 10, 2020
https://doi.org/10.1371/journal.pbio.3000696

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Notch signaling
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Embryos
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Transfection
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293T cells
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Green fluorescent protein
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