Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction

• Ashley L. Comer ,

  Contributed equally to this work with: Ashley L. Comer, Tushare Jinadasa

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Department of Biology, Boston University, Boston, Massachusetts, United States of America, The Graduate Program for Neuroscience, Boston University, Boston, Massachusetts, United States of America, Neurophotonics Center, Boston University, Boston, Massachusetts, United States of America

  http://orcid.org/0000-0002-7073-892X

  ⨯
• Tushare Jinadasa ,

  Contributed equally to this work with: Ashley L. Comer, Tushare Jinadasa

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Biology, Boston University, Boston, Massachusetts, United States of America, Neurophotonics Center, Boston University, Boston, Massachusetts, United States of America

  http://orcid.org/0000-0002-2693-9951

  ⨯
• Balaji Sriram,

  Roles Formal analysis, Methodology

  Affiliation Research and Early Development, Biogen, Cambridge, Massachusetts, United States of America

  http://orcid.org/0000-0002-9550-3190

  ⨯
• Rhushikesh A. Phadke,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Molecular Biology, Cell Biology and Biochemistry Program, Boston University, Boston, Massachusetts, United States of America

  ⨯
• Lisa N. Kretsge,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Biology, Boston University, Boston, Massachusetts, United States of America, The Graduate Program for Neuroscience, Boston University, Boston, Massachusetts, United States of America, Neurophotonics Center, Boston University, Boston, Massachusetts, United States of America

  ⨯
• Thanh P. H. Nguyen,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

  http://orcid.org/0000-0002-6177-5323

  ⨯
• Giovanna Antognetti,

  Roles Resources

  Affiliation Biologics Drug Discovery, Biogen, Cambridge, Massachusetts, United States of America

  ⨯
• James P. Gilbert,

  Roles Resources

  Affiliation External Innovations and New Indications, Biogen, Cambridge, Massachusetts, United States of America

  http://orcid.org/0000-0002-0947-4654

  ⨯
• Jungjoon Lee,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Department of Biology, Boston University, Boston, Massachusetts, United States of America

  ⨯
• Elena R. Newmark,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Department of Biology, Boston University, Boston, Massachusetts, United States of America

  http://orcid.org/0000-0003-3250-4126

  ⨯
• Frances S. Hausmann,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Department of Biology, Boston University, Boston, Massachusetts, United States of America

  http://orcid.org/0000-0001-5867-6642

  ⨯
• SaraAnn Rosenthal,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Department of Biology, Connecticut College, New London, Connecticut, United States of America

  ⨯
• Kevin Liu Kot,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Department of Biology, Boston University, Boston, Massachusetts, United States of America

  http://orcid.org/0000-0002-8019-4911

  ⨯
• Yenyu Liu,

  Roles Formal analysis, Methodology

  Affiliation Biochemistry and Molecular Biology/Biotechnology Program, Boston University, Boston, Massachusetts, United States of America

  ⨯
• William W. Yen,

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration

  Affiliations Department of Biology, Boston University, Boston, Massachusetts, United States of America, Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

  http://orcid.org/0000-0002-3536-3122

  ⨯
• Borislav Dejanovic,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

  ⨯
•  [ ... ],
• Alberto Cruz-Martín

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: acmartin@bu.edu

  Affiliations Department of Biology, Boston University, Boston, Massachusetts, United States of America, The Graduate Program for Neuroscience, Boston University, Boston, Massachusetts, United States of America, Neurophotonics Center, Boston University, Boston, Massachusetts, United States of America, Molecular Biology, Cell Biology and Biochemistry Program, Boston University, Boston, Massachusetts, United States of America, Department Pharmacology and Experimental Therapeutics, Boston University, Boston, Massachusetts, United States of America, Center for Systems Neuroscience, Boston University, Boston, Massachusetts, United States of America

  http://orcid.org/0000-0002-3271-7220

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