Should a viral genome stay in the host cell or leave? A quantitative dynamics study of how hepatitis C virus deals with this dilemma

• Shoya Iwanami ,

  Roles Formal analysis, Investigation, Project administration, Visualization, Writing – original draft

  ¶‡ S. Iwanami and KK contributed equally to this work. S. Iwami and KW also contributed equally to this work.

  Affiliation Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan

  http://orcid.org/0000-0003-1474-5348

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• Kosaku Kitagawa ,

  Roles Formal analysis, Writing – original draft

  ¶‡ S. Iwanami and KK contributed equally to this work. S. Iwami and KW also contributed equally to this work.

  Affiliation Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan

  http://orcid.org/0000-0003-3108-2152

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• Hirofumi Ohashi,

  Roles Formal analysis

  Affiliations Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan, Department of Applied Biological Science, Tokyo University of Science, Noda, Japan

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• Yusuke Asai,

  Roles Formal analysis, Visualization

  Affiliation Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan

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• Kaho Shionoya,

  Roles Investigation

  Affiliations Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan, Department of Applied Biological Science, Tokyo University of Science, Noda, Japan

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• Wakana Saso,

  Roles Investigation

  Affiliations Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

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• Kazane Nishioka,

  Roles Formal analysis

  Affiliations Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan, Department of Applied Biological Science, Tokyo University of Science, Noda, Japan

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• Hisashi Inaba,

  Roles Formal analysis

  Affiliation Graduate School of Mathematical Sciences, The University of Tokyo, Tokyo, Japan

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• Shinji Nakaoka,

  Roles Formal analysis

  Affiliations Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan, PRESTO, Japan Science and Technology Agency, Saitama, Japan

  http://orcid.org/0000-0002-3277-9552

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• Takaji Wakita,

  Roles Conceptualization, Formal analysis, Investigation

  Affiliation Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

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• Odo Diekmann,

  Roles Conceptualization, Writing – original draft

  Affiliation Mathematisch Institute, Universiteit Utrecht, Utrecht, the Netherlands

  http://orcid.org/0000-0003-4695-7601

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• Shingo Iwami ,

  Roles Conceptualization, Formal analysis, Investigation, Project administration, Supervision, Writing – original draft

  * E-mail: siwami@kyushu-u.org (SI); kwatashi@nih.go.jp (KW)

  ¶‡ S. Iwanami and KK contributed equally to this work. S. Iwami and KW also contributed equally to this work.

  Affiliations Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan, MIRAI, JST, Saitama, Japan, Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan, NEXT-Ganken Program, Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan, Science Groove, Inc., Fukuoka, Japan

  http://orcid.org/0000-0002-1780-350X

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• Koichi Watashi

  Roles Conceptualization, Formal analysis, Investigation, Project administration, Supervision, Writing – original draft

  * E-mail: siwami@kyushu-u.org (SI); kwatashi@nih.go.jp (KW)

  ¶‡ S. Iwanami and KK contributed equally to this work. S. Iwami and KW also contributed equally to this work.

  Affiliations Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan, Department of Applied Biological Science, Tokyo University of Science, Noda, Japan, MIRAI, JST, Saitama, Japan, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan

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