The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability

Fanwei Zeng; Xuehai Ma; Lin Zhu; Qiang Xu; Yuzhe Zeng; Yue Gao; Guilin Li; Tiantian Guo; Haibin Zhang; Xiaoyan Tang; Ziqiang Wang; Zesen Ye; Liangkai Zheng; Hongfeng Zhang; Qiuyang Zheng; Kunping Li; Jinfang Lu; Xueting Qi; Hong Luo; Xian Zhang; Zhanxiang Wang; Yulin Zhou; Yi Yao; Rongqin Ke; Ying Zhou; Yan Liu; Hao Sun; Timothy Huang; Zhicheng Shao; Huaxi Xu; Xin Wang

doi:10.1371/journal.pbio.3000525

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Open Access

Peer-reviewed

Research Article

The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability

Fanwei Zeng ,

Contributed equally to this work with: Fanwei Zeng, Xuehai Ma, Lin Zhu

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft

Affiliation State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China

http://orcid.org/0000-0001-6122-3302

⨯
Xuehai Ma ,

Contributed equally to this work with: Fanwei Zeng, Xuehai Ma, Lin Zhu

Roles Investigation, Methodology, Visualization

Affiliations State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China, School of Life Sciences, Xinjiang Normal University, Urumqi, China
⨯
Lin Zhu ,

Contributed equally to this work with: Fanwei Zeng, Xuehai Ma, Lin Zhu

Roles Formal analysis, Investigation, Methodology, Visualization

Affiliation State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China
⨯
Qiang Xu,

Roles Investigation, Visualization

Affiliation State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China
⨯
Yuzhe Zeng,

Roles Investigation, Visualization

Affiliation State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China
⨯
Yue Gao,

Roles Investigation

Affiliation State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China
⨯
Guilin Li,

Roles Investigation

Affiliation State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China
⨯
Tiantian Guo,

Roles Investigation

Affiliation State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China
⨯
Haibin Zhang,

Roles Investigation, Visualization

Affiliation State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China
⨯
Xiaoyan Tang,

Roles Investigation

Affiliation Institute for Stem Cell and Neural Regeneration, School of Pharmacy, Nanjing Medical University, Nanjing, China

http://orcid.org/0000-0002-5536-5117

⨯
Ziqiang Wang,

Roles Investigation

Affiliation School of Biomedical Sciences, Huaqiao University, Quanzhou, China
⨯
Zesen Ye,

Roles Investigation

Affiliations State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China, Department of Neurosurgery, the First Affiliated Hospital of Xiamen University, Xiamen, China
⨯
Liangkai Zheng,

Roles Resources

Affiliation Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, China
⨯
Hongfeng Zhang,

Roles Methodology

Affiliation State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China
⨯
Qiuyang Zheng,

Roles Methodology

Affiliation State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China
⨯
Kunping Li,

Roles Investigation

Affiliation State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China
⨯
Jinfang Lu,

Roles Investigation

Affiliation State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China
⨯
Xueting Qi,

Roles Investigation

Affiliation State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China
⨯
Hong Luo,

Roles Methodology

Affiliation State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China
⨯
Xian Zhang,

Roles Methodology

Affiliation State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China

http://orcid.org/0000-0003-3905-0489

⨯
Zhanxiang Wang,

Roles Methodology

Affiliations State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China, Department of Neurosurgery, the First Affiliated Hospital of Xiamen University, Xiamen, China
⨯
Yulin Zhou,

Roles Resources

Affiliation Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, China
⨯
Yi Yao,

Roles Resources

Affiliation Department of Functional Neurosurgery, Xiamen Humanity Hospital, Xiamen, China
⨯
Rongqin Ke,

Roles Methodology

Affiliation School of Biomedical Sciences, Huaqiao University, Quanzhou, China
⨯
Ying Zhou,

Roles Formal analysis, Methodology

Affiliation Department of Translational Medicine, School of Medicine, Xiamen University, Xiamen, China
⨯
Yan Liu,

Roles Methodology

Affiliation Institute for Stem Cell and Neural Regeneration, School of Pharmacy, Nanjing Medical University, Nanjing, China
⨯
Hao Sun,

Roles Methodology

Affiliation State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China
⨯
Timothy Huang,

Roles Writing – review & editing

Affiliation Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, United States of America
⨯
Zhicheng Shao,

Roles Methodology

Affiliation State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China
⨯
Huaxi Xu,

Roles Writing – review & editing

Affiliation Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, United States of America
⨯
[ ... ],
Xin Wang

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: wangx@xmu.edu.cn

Affiliation State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China
⨯
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The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability

Fanwei Zeng,
Xuehai Ma,
Lin Zhu,
Qiang Xu,
Yuzhe Zeng,
Yue Gao,
Guilin Li,
Tiantian Guo,
Haibin Zhang,
Xiaoyan Tang

Published: December 16, 2019
https://doi.org/10.1371/journal.pbio.3000525

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