Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation

• Cynthia J. Sakofsky,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, North Carolina, United States of America

  http://orcid.org/0000-0002-0959-3688

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• Natalie Saini,

  Roles Formal analysis, Writing – review & editing

  Affiliation Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, North Carolina, United States of America

  http://orcid.org/0000-0002-1668-5417

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• Leszek J. Klimczak,

  Roles Software

  Affiliation Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, US National Institutes of Health, North Carolina, United States of America

  http://orcid.org/0000-0003-3048-2576

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• Kin Chan,

  Roles Investigation, Methodology

  Current address: Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada

  Affiliation Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, North Carolina, United States of America

  http://orcid.org/0000-0002-5827-3154

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• Ewa P. Malc,

  Roles Investigation

  Affiliation Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America

  http://orcid.org/0000-0002-4596-1142

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• Piotr A. Mieczkowski,

  Roles Investigation

  Affiliation Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America

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• Adam B. Burkholder,

  Roles Software

  Affiliation Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, US National Institutes of Health, North Carolina, United States of America

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• David Fargo,

  Roles Software

  Affiliation Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, US National Institutes of Health, North Carolina, United States of America

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• Dmitry A. Gordenin

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: gordenin@niehs.nih.gov

  Affiliation Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, North Carolina, United States of America

  http://orcid.org/0000-0002-8399-1836

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