Activation of the intrinsic fibroinflammatory program in adult pancreatic acinar cells triggered by Hippo signaling disruption

Jun Liu; Ming Gao; Michael Nipper; Janice Deng; Francis E. Sharkey; Randy L. Johnson; Howard C. Crawford; Yidong Chen; Pei Wang

doi:10.1371/journal.pbio.3000418

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Open Access

Peer-reviewed

Research Article

Activation of the intrinsic fibroinflammatory program in adult pancreatic acinar cells triggered by Hippo signaling disruption

Jun Liu ,

Contributed equally to this work with: Jun Liu, Ming Gao

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation Department of Cell Systems & Anatomy, UT Health San Antonio, San Antonio, Texas, United States of America
⨯
Ming Gao ,

Contributed equally to this work with: Jun Liu, Ming Gao

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation Department of Cell Systems & Anatomy, UT Health San Antonio, San Antonio, Texas, United States of America
⨯
Michael Nipper,

Roles Writing – review & editing

Affiliation Department of Cell Systems & Anatomy, UT Health San Antonio, San Antonio, Texas, United States of America
⨯
Janice Deng,

Roles Data curation

Affiliation Department of Cell Systems & Anatomy, UT Health San Antonio, San Antonio, Texas, United States of America
⨯
Francis E. Sharkey,

Roles Formal analysis

Affiliation Department of Pathology, UT Health San Antonio, San Antonio, Texas, United States of America

http://orcid.org/0000-0002-7398-3285

⨯
Randy L. Johnson,

Roles Resources

Affiliation Department of Cancer Biology, Division of Basic Science Research, the University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

http://orcid.org/0000-0003-4549-3593

⨯
Howard C. Crawford,

Roles Methodology

Affiliation Department of Molecular and Integrative Physiology & Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America
⨯
Yidong Chen,

Roles Methodology

Affiliation Department of Epidemiology Biostatistics, UT Health San Antonio, San Antonio, Texas, United States of America

http://orcid.org/0000-0001-6806-2185

⨯
Pei Wang

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: wangp3@uthscsa.edu

Affiliation Department of Cell Systems & Anatomy, UT Health San Antonio, San Antonio, Texas, United States of America

http://orcid.org/0000-0003-2373-7315

⨯

Activation of the intrinsic fibroinflammatory program in adult pancreatic acinar cells triggered by Hippo signaling disruption

Jun Liu,
Ming Gao,
Michael Nipper,
Janice Deng,
Francis E. Sharkey,
Randy L. Johnson,
Howard C. Crawford,
Yidong Chen,
Pei Wang

Published: September 12, 2019
https://doi.org/10.1371/journal.pbio.3000418

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Inflammation
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Pancreas
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Cell disruption
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