MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis

• Dongyeop Lee ,

  Contributed equally to this work with: Dongyeop Lee, Seon Woo A. An, Yoonji Jung

  Roles Conceptualization, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

  Affiliation Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea

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• Seon Woo A. An ,

  Contributed equally to this work with: Dongyeop Lee, Seon Woo A. An, Yoonji Jung

  Roles Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yuseong-gu, Daejeon, South Korea

  ⨯
• Yoonji Jung ,

  Contributed equally to this work with: Dongyeop Lee, Seon Woo A. An, Yoonji Jung

  Roles Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yuseong-gu, Daejeon, South Korea

  ⨯
• Yasuyo Yamaoka,

  Roles Investigation

  Affiliation Department of Integrative Bioscience & Biotechnology, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea

  ⨯
• Youngjae Ryu,

  Roles Investigation

  Affiliation Research Division and Brain Research Core Facilities, Korea Brain Research Institute, Daegu, South Korea

  ⨯
• Grace Ying Shyen Goh,

  Roles Investigation

  Affiliation Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada

  ⨯
• Arshia Beigi,

  Roles Investigation

  Affiliation Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada

  ⨯
• Jae-Seong Yang,

  Roles Investigation

  Affiliation Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea

  ⨯
• Gyoo Yeol Jung,

  Roles Investigation

  Affiliations Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea, School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea

  http://orcid.org/0000-0002-9742-3207

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• Dengke K. Ma,

  Roles Investigation

  Affiliation Cardiovascular Research Institute and Department of Physiology, University of California San Francisco, San Francisco, California, United States of America

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• Chang Man Ha,

  Roles Investigation

  Affiliation Research Division and Brain Research Core Facilities, Korea Brain Research Institute, Daegu, South Korea

  ⨯
• Stefan Taubert,

  Roles Investigation, Writing – review & editing

  Affiliation Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada

  http://orcid.org/0000-0002-2432-7257

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• Youngsook Lee,

  Roles Investigation

  Affiliations Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea, Department of Integrative Bioscience & Biotechnology, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea

  http://orcid.org/0000-0002-5808-9613

  ⨯
• Seung-Jae V. Lee

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: seungjaevlee@kaist.ac.kr

  Affiliation Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yuseong-gu, Daejeon, South Korea

  http://orcid.org/0000-0002-6103-156X

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