A kinase-dependent checkpoint prevents escape of immature ribosomes into the translating pool

Melissa D. Parker; Jason C. Collins; Boguslawa Korona; Homa Ghalei; Katrin Karbstein

doi:10.1371/journal.pbio.3000329

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Open Access

Peer-reviewed

Research Article

A kinase-dependent checkpoint prevents escape of immature ribosomes into the translating pool

Melissa D. Parker,

Roles Conceptualization, Formal analysis, Investigation, Resources, Writing – original draft, Writing – review & editing

Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, Jupiter, Florida, United States of America

http://orcid.org/0000-0002-8816-8355

⨯
Jason C. Collins,

Roles Formal analysis, Investigation, Writing – review & editing

Current address: Stem Cell Biochemistry Unit, National Institute of Dental and Craniofacial Research, Bethesda, Maryland, United States of America

Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, Jupiter, Florida, United States of America

http://orcid.org/0000-0002-7653-0070

⨯
Boguslawa Korona,

Roles Formal analysis, Investigation, Resources

Current address: Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom

Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, Jupiter, Florida, United States of America
⨯
Homa Ghalei,

Roles Formal analysis, Investigation, Resources

Current address: Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, United States of America

Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, Jupiter, Florida, United States of America

http://orcid.org/0000-0003-0168-4654

⨯
Katrin Karbstein

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: kkarbst@scripps.edu

Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, Jupiter, Florida, United States of America, HHMI Faculty Scholar, Chevy Chase, Maryland, United States of America

http://orcid.org/0000-0002-4034-1331

⨯

A kinase-dependent checkpoint prevents escape of immature ribosomes into the translating pool

Melissa D. Parker,
Jason C. Collins,
Boguslawa Korona,
Homa Ghalei,
Katrin Karbstein

Published: December 13, 2019
https://doi.org/10.1371/journal.pbio.3000329

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Ribosomes
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Ribosomal RNA
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Polyribosomes
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Northern blot
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Messenger RNA
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Binding analysis
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