Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy

• Yun-Chi Lu ,

  Contributed equally to this work with: Yun-Chi Lu, Chih-Hung Chuang

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft

  Affiliation Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

  ⨯
• Chih-Hung Chuang ,

  Contributed equally to this work with: Yun-Chi Lu, Chih-Hung Chuang

  Roles Conceptualization, Writing – original draft

  Affiliations Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan

  http://orcid.org/0000-0002-1221-6584

  ⨯
• Kuo-Hsiang Chuang,

  Roles Project administration, Writing – review & editing

  Affiliation Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan

  http://orcid.org/0000-0001-7513-2671

  ⨯
• I-Ju Chen,

  Roles Conceptualization, Data curation

  Affiliations Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan, Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan

  ⨯
• Bo-Cheng Huang,

  Roles Investigation

  Affiliation Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan

  ⨯
• Wen-Han Lee,

  Roles Data curation, Formal analysis, Investigation, Validation

  Affiliation Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan

  ⨯
• Hsin-Ell Wang,

  Roles Supervision, Visualization

  Affiliations Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, Biophotonics and Molecular Imaging Research Center, National Yang-Ming University, Taipei, Taiwan

  ⨯
• Jia-Je Li,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan

  ⨯
• Yi-An Cheng,

  Roles Methodology

  Affiliation Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

  ⨯
• Kai-Wen Cheng,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan

  ⨯
• Jaw-Yuan Wang,

  Roles Methodology

  Affiliations Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Division of Gastroenterology and General Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

  ⨯
• Yuan-Chin Hsieh,

  Roles Methodology, Software

  Affiliation Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan

  ⨯
• Wen-Wei Lin ,

  Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: weber06272000@gmail.com (WWL); tlcheng@kmu.edu.tw (TLC)

  Affiliations Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan, Department of Laboratory Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

  ⨯
• Tian-Lu Cheng

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: weber06272000@gmail.com (WWL); tlcheng@kmu.edu.tw (TLC)

  Affiliations Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan, Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan, Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

  http://orcid.org/0000-0003-0004-8840

  ⨯