Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR

• Xiaoli Zhang ,

  Contributed equally to this work with: Xiaoli Zhang, Wei Chen

  Roles Conceptualization, Data curation, Formal analysis, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

  http://orcid.org/0000-0002-0507-6317

  ⨯
• Wei Chen ,

  Contributed equally to this work with: Xiaoli Zhang, Wei Chen

  Roles Data curation, Formal analysis, Validation

  Affiliation Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Qiong Gao,

  Roles Data curation, Formal analysis, Writing – original draft

  Affiliation Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

  http://orcid.org/0000-0002-5281-7392

  ⨯
• Junsheng Yang,

  Roles Data curation

  Affiliations Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China

  http://orcid.org/0000-0002-6425-8495

  ⨯
• Xueni Yan,

  Roles Data curation

  Affiliation Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China

  ⨯
• Han Zhao,

  Roles Data curation

  Affiliation Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China

  ⨯
• Lin Su,

  Roles Data curation

  Affiliation Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China

  ⨯
• Meimei Yang,

  Roles Data curation

  Affiliations Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Neurology, The Fourth Hospital of Harbin Medical University, Harbin, China

  ⨯
• Chenlang Gao,

  Roles Data curation

  Affiliation Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

  http://orcid.org/0000-0003-1569-9101

  ⨯
• Yao Yao,

  Roles Data curation

  Affiliation Department of Integrative and Molecular Physiology and Internal Medicine, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Ken Inoki,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Integrative and Molecular Physiology and Internal Medicine, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Dan Li,

  Roles Data curation

  Affiliation Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China

  ⨯
• Rong Shao,

  Roles Data curation

  Affiliation Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China

  ⨯
• Shiyi Wang,

  Roles Data curation

  Affiliation Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Nirakar Sahoo,

  Roles Data curation

  Affiliation Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

  http://orcid.org/0000-0003-0669-3840

  ⨯
• Fumitaka Kudo,

  Roles Methodology

  Affiliation Department of Chemistry, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo, Japan

  http://orcid.org/0000-0002-4788-0063

  ⨯
• Tadashi Eguchi,

  Roles Methodology

  Affiliation Department of Chemistry, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo, Japan

  http://orcid.org/0000-0002-7830-7104

  ⨯
• Benfang Ruan ,

  Roles Data curation, Formal analysis, Validation, Writing – original draft

  * E-mail: haoxingx@umich.edu (HX); ruanbf@zjut.edu.cn (BR)

  Affiliation Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China

  http://orcid.org/0000-0001-9981-8328

  ⨯
•  [ ... ],
• Haoxing Xu

  Roles Conceptualization, Project administration, Supervision, Writing – review & editing

  * E-mail: haoxingx@umich.edu (HX); ruanbf@zjut.edu.cn (BR)

  Affiliation Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

  http://orcid.org/0000-0003-3561-4654

  ⨯
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