Structural basis for neutralization of hepatitis A virus informs a rational design of highly potent inhibitors

• Lei Cao ,

  Contributed equally to this work with: Lei Cao, Pi Liu, Pan Yang

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations CAS Key Laboratory of Infection and Immunity, CAS Centre for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu, China, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

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• Pi Liu ,

  Contributed equally to this work with: Lei Cao, Pi Liu, Pan Yang

  Roles Data curation, Formal analysis, Methodology, Resources, Software, Validation, Visualization

  Affiliation Biodesign Center, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China

  http://orcid.org/0000-0001-5064-3053

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• Pan Yang ,

  Contributed equally to this work with: Lei Cao, Pi Liu, Pan Yang

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization

  Affiliations CAS Key Laboratory of Infection and Immunity, CAS Centre for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

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• Qiang Gao,

  Roles Data curation, Resources

  Affiliation Sinovac Biotech Co., Ltd., Beijing, China

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• Hong Li,

  Roles Investigation, Methodology, Software, Visualization

  Affiliation Tianjin International Biomedical Joint Research Institute, Tianjin, China

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• Yao Sun,

  Roles Data curation, Investigation, Resources, Validation, Visualization

  Affiliations CAS Key Laboratory of Infection and Immunity, CAS Centre for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

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• Ling Zhu,

  Roles Data curation, Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliations CAS Key Laboratory of Infection and Immunity, CAS Centre for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

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• Jianping Lin,

  Roles Methodology, Software, Supervision, Validation

  Affiliation Biodesign Center, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China

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• Dan Su ,

  Roles Conceptualization, Formal analysis, Project administration, Supervision, Writing – review & editing

  * E-mail: xiangxi@ibp.ac.cn (XW); raozh@xtal.tsinghua.edu.cn (ZR); sudan@scu.edu.cn (DS)

  Affiliation State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu, China

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• Zihe Rao ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: xiangxi@ibp.ac.cn (XW); raozh@xtal.tsinghua.edu.cn (ZR); sudan@scu.edu.cn (DS)

  Affiliations National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, Tianjin International Biomedical Joint Research Institute, Tianjin, China, Laboratory of Structural Biology, School of Medicine, Tsinghua University, Beijing, China

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• Xiangxi Wang

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: xiangxi@ibp.ac.cn (XW); raozh@xtal.tsinghua.edu.cn (ZR); sudan@scu.edu.cn (DS)

  Affiliations CAS Key Laboratory of Infection and Immunity, CAS Centre for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

  http://orcid.org/0000-0003-0635-278X

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