Combinatorial mutagenesis of rapidly evolving residues yields super-restrictor antiviral proteins

• Rossana Colón-Thillet,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, United States of America

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• Emily Hsieh ,

  Contributed equally to this work with: Emily Hsieh, Laura Graf

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliations Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, United States of America, Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

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• Laura Graf ,

  Contributed equally to this work with: Emily Hsieh, Laura Graf

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Institute of Virology, Medical Center-University of Freiburg, Freiburg, Germany

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• Richard N. McLaughlin Jr,

  Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Pacific Northwest Research Institute, Seattle, Washington, United States of America

  http://orcid.org/0000-0003-0950-2253

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• Janet M. Young,

  Roles Formal analysis, Visualization, Writing – review & editing

  Affiliation Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  http://orcid.org/0000-0001-8220-8427

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• Georg Kochs,

  Roles Data curation, Investigation, Supervision, Writing – review & editing

  Affiliations Institute of Virology, Medical Center-University of Freiburg, Freiburg, Germany, Faculty of Medicine, University of Freiburg, Freiburg, Germany

  http://orcid.org/0000-0003-0187-559X

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• Michael Emerman,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  http://orcid.org/0000-0002-4181-6335

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• Harmit S. Malik

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: hsmalik@fredhutch.org

  Affiliations Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

  http://orcid.org/0000-0001-6005-0016

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