Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen

• Fabian Sesterhenn,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland

  http://orcid.org/0000-0001-8331-4344

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• Marie Galloux,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Unité de Virologie et Immunologie Moléculaires (UR892), INRA, Université Paris-Saclay, Jouy-en-Josas, France

  http://orcid.org/0000-0001-7477-8489

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• Sabrina S. Vollers,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

  http://orcid.org/0000-0002-6772-0155

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• Lucia Csepregi,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland

  http://orcid.org/0000-0002-0709-4244

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• Che Yang,

  Roles Investigation, Writing – review & editing

  Affiliations Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland

  http://orcid.org/0000-0002-4591-5373

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• Delphyne Descamps,

  Roles Investigation, Writing – review & editing

  Affiliation Unité de Virologie et Immunologie Moléculaires (UR892), INRA, Université Paris-Saclay, Jouy-en-Josas, France

  http://orcid.org/0000-0002-4883-6910

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• Jaume Bonet,

  Roles Investigation, Writing – review & editing

  Affiliations Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland

  http://orcid.org/0000-0001-5210-4387

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• Simon Friedensohn,

  Roles Data curation, Formal analysis, Investigation, Software, Writing – review & editing

  Affiliation Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland

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• Pablo Gainza,

  Roles Investigation, Writing – review & editing

  Affiliations Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland

  http://orcid.org/0000-0001-9197-0982

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• Patricia Corthésy,

  Roles Investigation

  Affiliation Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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• Man Chen,

  Roles Investigation

  Affiliation Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Stéphane Rosset,

  Roles Investigation

  Affiliation Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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• Marie-Anne Rameix-Welti,

  Roles Investigation, Writing – review & editing

  Affiliations UMR1173, INSERM, Université de Versailles St. Quentin, Montigny le Bretonneux, France, AP-HP, Laboratoire de Microbiologie, Hôpital Ambroise Paré, Boulogne-Billancourt, France

  http://orcid.org/0000-0002-5901-3856

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• Jean-François Éléouët,

  Roles Supervision, Writing – review & editing

  Affiliation Unité de Virologie et Immunologie Moléculaires (UR892), INRA, Université Paris-Saclay, Jouy-en-Josas, France

  http://orcid.org/0000-0002-7361-4885

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• Sai T. Reddy,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliation Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland

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• Barney S. Graham,

  Roles Supervision, Writing – review & editing

  Affiliation Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Sabine Riffault,

  Roles Supervision, Writing – review & editing

  Affiliation Unité de Virologie et Immunologie Moléculaires (UR892), INRA, Université Paris-Saclay, Jouy-en-Josas, France

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•  [ ... ],
• Bruno E. Correia

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: bruno.correia@epfl.ch

  Affiliations Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland

  http://orcid.org/0000-0002-7377-8636

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