Astroglial dysfunctions drive aberrant synaptogenesis and social behavioral deficits in mice with neonatal exposure to lengthy general anesthesia

• Bin Zhou ,

  Contributed equally to this work with: Bin Zhou, Lingmin Chen

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Laboratory of Anesthesia and Critical Care Medicine, Sichuan University, Chengdu, Sichuan, China, Translational Neuroscience Center, Sichuan University, Chengdu, Sichuan, China, Department of Anesthesiology of West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Lingmin Chen ,

  Contributed equally to this work with: Bin Zhou, Lingmin Chen

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Laboratory of Anesthesia and Critical Care Medicine, Sichuan University, Chengdu, Sichuan, China, Translational Neuroscience Center, Sichuan University, Chengdu, Sichuan, China, Department of Anesthesiology of West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Ping Liao,

  Roles Data curation, Investigation, Methodology

  Affiliations Laboratory of Anesthesia and Critical Care Medicine, Sichuan University, Chengdu, Sichuan, China, Translational Neuroscience Center, Sichuan University, Chengdu, Sichuan, China, Department of Anesthesiology of West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Lu Huang,

  Roles Data curation, Formal analysis, Investigation

  Affiliations Laboratory of Anesthesia and Critical Care Medicine, Sichuan University, Chengdu, Sichuan, China, Translational Neuroscience Center, Sichuan University, Chengdu, Sichuan, China, Department of Anesthesiology of West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Zhuo Chen,

  Roles Investigation

  Affiliations Laboratory of Anesthesia and Critical Care Medicine, Sichuan University, Chengdu, Sichuan, China, Translational Neuroscience Center, Sichuan University, Chengdu, Sichuan, China, Department of Anesthesiology of West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Daqing Liao,

  Roles Investigation, Resources

  Affiliations Laboratory of Anesthesia and Critical Care Medicine, Sichuan University, Chengdu, Sichuan, China, Translational Neuroscience Center, Sichuan University, Chengdu, Sichuan, China, Department of Anesthesiology of West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Linghui Yang,

  Roles Methodology, Resources

  Affiliations Laboratory of Anesthesia and Critical Care Medicine, Sichuan University, Chengdu, Sichuan, China, Translational Neuroscience Center, Sichuan University, Chengdu, Sichuan, China, Department of Anesthesiology of West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Jing Wang,

  Roles Methodology, Resources

  Affiliations Laboratory of Anesthesia and Critical Care Medicine, Sichuan University, Chengdu, Sichuan, China, Translational Neuroscience Center, Sichuan University, Chengdu, Sichuan, China, Department of Anesthesiology of West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Guoqiang Yu,

  Roles Investigation, Methodology

  Affiliation Bradley Department of Electrical & Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, Virginia, United States of America

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• Li Wang,

  Roles Investigation, Methodology

  Affiliation Center for Biological Imaging, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

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• Jianguo Zhang,

  Roles Investigation, Methodology

  Affiliation Center for Biological Imaging, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

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• Yunxia Zuo,

  Roles Conceptualization, Resources

  Affiliations Laboratory of Anesthesia and Critical Care Medicine, Sichuan University, Chengdu, Sichuan, China, Translational Neuroscience Center, Sichuan University, Chengdu, Sichuan, China, Department of Anesthesiology of West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Jin Liu,

  Roles Funding acquisition, Project administration, Resources

  Affiliations Laboratory of Anesthesia and Critical Care Medicine, Sichuan University, Chengdu, Sichuan, China, Translational Neuroscience Center, Sichuan University, Chengdu, Sichuan, China, Department of Anesthesiology of West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Ruotian Jiang

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: ruotianjiang@scu.edu.cn

  Affiliations Laboratory of Anesthesia and Critical Care Medicine, Sichuan University, Chengdu, Sichuan, China, Translational Neuroscience Center, Sichuan University, Chengdu, Sichuan, China, Department of Anesthesiology of West China Hospital, Sichuan University, Chengdu, Sichuan, China

  http://orcid.org/0000-0001-5322-6802

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