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Open Access
Peer-reviewed
Research Article
miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity
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Marcin Łyszkiewicz ,
Contributed equally to this work with: Marcin Łyszkiewicz, Samantha J. Winter, Natalia Ziętara, Andreas Krueger
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing
Affiliations Institute of Immunology, Hannover Medical School, Hannover, Germany, Institute for Immunology, Ludwig-Maximilians University, Planegg-Martiensried, Germany
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Samantha J. Winter ,
Contributed equally to this work with: Marcin Łyszkiewicz, Samantha J. Winter, Natalia Ziętara, Andreas Krueger
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing
Affiliation Institute for Molecular Medicine, Goethe University Frankfurt am Main, Frankfurt, Germany
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Katrin Witzlau,
Roles Investigation, Methodology
Affiliation Institute of Immunology, Hannover Medical School, Hannover, Germany
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Lisa Föhse,
Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization
Affiliation Institute of Immunology, Hannover Medical School, Hannover, Germany
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Rebecca Brownlie,
Roles Formal analysis, Investigation, Methodology
Affiliation Institute for Immunology and Infection Research, The University of Edinburgh, Edinburgh, United Kingdom
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Jacek Puchałka,
Roles Data curation, Formal analysis, Methodology, Software
Affiliation Department of Pediatrics, Dr. von Hauner Kinderspital, Ludwig-Maximilians University, Munich, Germany
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Nikita A. Verheyden,
Roles Data curation, Formal analysis, Visualization, Writing – review & editing
Affiliation Institute for Molecular Medicine, Goethe University Frankfurt am Main, Frankfurt, Germany
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Heike Kunze-Schumacher,
Roles Data curation, Investigation, Validation
Affiliation Institute for Molecular Medicine, Goethe University Frankfurt am Main, Frankfurt, Germany
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Esther Imelmann,
Roles Investigation, Methodology
Affiliation Institute for Molecular Medicine, Goethe University Frankfurt am Main, Frankfurt, Germany
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Jonas Blume,
Roles Formal analysis, Investigation, Methodology, Visualization
Current address: The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Australia
Affiliation Institute of Immunology, Hannover Medical School, Hannover, Germany
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Solaiman Raha,
Roles Data curation, Formal analysis, Software, Validation
Affiliation Institute of Immunology, Hannover Medical School, Hannover, Germany
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Takashi Sekiya,
Roles Methodology, Resources
Affiliation Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
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Akihiko Yoshimura,
Roles Methodology, Resources
Affiliation Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
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Jochen T. Frueh,
Roles Investigation, Methodology, Resources
Affiliations Experimental Immunology, Department for Children and Adolescents Medicine, Hospital of the Goethe University Frankfurt, Frankfurt, Germany, LOEWE Center for Cell and Gene Therapy, Goethe University, Frankfurt, Germany
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Evelyn Ullrich,
Roles Methodology, Resources
Affiliations Experimental Immunology, Department for Children and Adolescents Medicine, Hospital of the Goethe University Frankfurt, Frankfurt, Germany, LOEWE Center for Cell and Gene Therapy, Goethe University, Frankfurt, Germany
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Jochen Huehn,
Roles Formal analysis, Resources
Affiliation Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
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Siegfried Weiss,
Roles Data curation, Formal analysis, Resources
Affiliation Institute of Immunology, Hannover Medical School, Hannover, Germany
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Maximiliano G. Gutierrez,
Roles Data curation, Formal analysis, Funding acquisition, Methodology, Supervision, Validation, Writing – review & editing
Affiliation The Francis Crick Institute, London, England, United Kingdom
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Immo Prinz,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – review & editing
Affiliation Institute of Immunology, Hannover Medical School, Hannover, Germany
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Rose Zamoyska,
Roles Formal analysis, Investigation, Methodology, Supervision
Affiliation Institute for Immunology and Infection Research, The University of Edinburgh, Edinburgh, United Kingdom
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Natalia Ziętara ,
Contributed equally to this work with: Marcin Łyszkiewicz, Samantha J. Winter, Natalia Ziętara, Andreas Krueger
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: andreas.krueger@kgu.de (AK); natalia.zietara@med.uni-muenchen.de (NZ)
Affiliations Institute of Immunology, Hannover Medical School, Hannover, Germany, Institute for Immunology, Ludwig-Maximilians University, Planegg-Martiensried, Germany
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Andreas Krueger
Contributed equally to this work with: Marcin Łyszkiewicz, Samantha J. Winter, Natalia Ziętara, Andreas Krueger
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: andreas.krueger@kgu.de (AK); natalia.zietara@med.uni-muenchen.de (NZ)
Affiliations Institute of Immunology, Hannover Medical School, Hannover, Germany, Institute for Molecular Medicine, Goethe University Frankfurt am Main, Frankfurt, Germany
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miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity
- Marcin Łyszkiewicz,
- Samantha J. Winter,
- Katrin Witzlau,
- Lisa Föhse,
- Rebecca Brownlie,
- Jacek Puchałka,
- Nikita A. Verheyden,
- Heike Kunze-Schumacher,
- Esther Imelmann,
- Jonas Blume
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- Published: March 11, 2019
- https://doi.org/10.1371/journal.pbio.2006716