EpCAM ectodomain EpEX is a ligand of EGFR that counteracts EGF-mediated epithelial-mesenchymal transition through modulation of phospho-ERK1/2 in head and neck cancers

• Min Pan ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  ¶‡ MP and HS contributed equally to this work. PB and OG also contributed equally to this work.

  Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig-Maximilians-University, Munich, Germany

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• Henrik Schinke ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Writing – review & editing

  ¶‡ MP and HS contributed equally to this work. PB and OG also contributed equally to this work.

  Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig-Maximilians-University, Munich, Germany

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• Elke Luxenburger,

  Roles Data curation, Investigation, Methodology, Visualization

  Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig-Maximilians-University, Munich, Germany

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• Gisela Kranz,

  Roles Data curation, Formal analysis, Methodology, Visualization

  Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig-Maximilians-University, Munich, Germany

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• Julius Shakhtour,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig-Maximilians-University, Munich, Germany

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• Darko Libl,

  Roles Methodology

  Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig-Maximilians-University, Munich, Germany

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• Yuanchi Huang,

  Roles Formal analysis, Methodology, Validation

  Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig-Maximilians-University, Munich, Germany

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• Aljaž Gaber,

  Roles Formal analysis, Methodology

  Affiliation Department of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia

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• Miha Pavšič,

  Roles Methodology, Supervision

  Affiliation Department of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia

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• Brigita Lenarčič,

  Roles Methodology, Supervision

  Affiliations Department of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia, Department of Biochemistry, Molecular and Structural Biology, Institute Jožef Stefan, Ljubljana, Slovenia

  ⨯
• Julia Kitz,

  Roles Data curation, Investigation, Resources

  Affiliation Institute of Pathology, University Medical Center, Göttingen, Germany

  ⨯
• Mark Jakob,

  Roles Data curation, Investigation, Resources

  Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig-Maximilians-University, Munich, Germany

  ⨯
• Sabina Schwenk-Zieger,

  Roles Methodology

  Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig-Maximilians-University, Munich, Germany

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• Martin Canis,

  Roles Data curation, Investigation, Resources, Supervision

  Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig-Maximilians-University, Munich, Germany

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• Julia Hess,

  Roles Data curation, Formal analysis, Methodology, Software

  Affiliations Clinical Cooperation Group “Personalized Radiotherapy in Head and Neck Cancer“, Helmholtz Zentrum München, Research Center for Environmental Health (GmbH), Neuherberg, Germany, Research Unit Radiation Cytogenetics, Helmholtz Zentrum München, Research Center for Environmental Health (GmbH), Neuherberg, Germany

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• Kristian Unger,

  Roles Data curation, Formal analysis, Methodology, Software

  Affiliations Clinical Cooperation Group “Personalized Radiotherapy in Head and Neck Cancer“, Helmholtz Zentrum München, Research Center for Environmental Health (GmbH), Neuherberg, Germany, Research Unit Radiation Cytogenetics, Helmholtz Zentrum München, Research Center for Environmental Health (GmbH), Neuherberg, Germany

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• Philipp Baumeister ,

  Roles Data curation, Formal analysis, Investigation, Resources, Supervision, Writing – review & editing

  ¶‡ MP and HS contributed equally to this work. PB and OG also contributed equally to this work.

  Affiliations Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig-Maximilians-University, Munich, Germany, Clinical Cooperation Group “Personalized Radiotherapy in Head and Neck Cancer“, Helmholtz Zentrum München, Research Center for Environmental Health (GmbH), Neuherberg, Germany

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•  [ ... ],
• Olivier Gires

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: Olivier.gires@med.uni-muenchen.de

  ¶‡ MP and HS contributed equally to this work. PB and OG also contributed equally to this work.

  Affiliations Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center, Ludwig-Maximilians-University, Munich, Germany, Clinical Cooperation Group “Personalized Radiotherapy in Head and Neck Cancer“, Helmholtz Zentrum München, Research Center for Environmental Health (GmbH), Neuherberg, Germany

  http://orcid.org/0000-0002-2292-7064

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