Nicotine exposure of male mice produces behavioral impairment in multiple generations of descendants

Deirdre M. McCarthy; Thomas J. Morgan Jr.; Sarah E. Lowe; Matthew J. Williamson; Thomas J. Spencer; Joseph Biederman; Pradeep G. Bhide

doi:10.1371/journal.pbio.2006497

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Nicotine exposure of male mice produces behavioral impairment in multiple generations of descendants

Deirdre M. McCarthy,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Center for Brain Repair, Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida, United States of America
⨯
Thomas J. Morgan Jr.,

Roles Conceptualization, Data curation, Investigation, Methodology

Current address: School of Physician Assistant Practice, Florida State University, Tallahassee, Florida, United States of America

Affiliation Center for Brain Repair, Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida, United States of America
⨯
Sarah E. Lowe,

Roles Data curation, Investigation, Methodology

Affiliation Center for Brain Repair, Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida, United States of America
⨯
Matthew J. Williamson,

Roles Data curation, Investigation

Affiliation Center for Brain Repair, Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida, United States of America
⨯
Thomas J. Spencer,

Roles Conceptualization, Writing – review & editing

Affiliation Pediatric Psychopharmacology, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Joseph Biederman,

Roles Conceptualization, Writing – review & editing

Affiliation Pediatric Psychopharmacology, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Pradeep G. Bhide

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: pradeep.bhide@med.fsu.edu

Affiliation Center for Brain Repair, Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida, United States of America

http://orcid.org/0000-0003-4236-9415

⨯

Nicotine exposure of male mice produces behavioral impairment in multiple generations of descendants

Deirdre M. McCarthy,
Thomas J. Morgan Jr.,
Sarah E. Lowe,
Matthew J. Williamson,
Thomas J. Spencer,
Joseph Biederman,
Pradeep G. Bhide

Published: October 16, 2018
https://doi.org/10.1371/journal.pbio.2006497

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24 Oct 2018
05:54 GMT
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Nicotine causes transgenerational effects across species Posted by abhaysharma on 24 Oct 2018 at 05:54 GMT
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23 Oct 2018
14:03 GMT
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Paternal transmission of environmental effects across generations indeed calls for public policy debate Posted by abhaysharma on 23 Oct 2018 at 14:03 GMT

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Nicotine
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Dopamine
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Nicotine replacement therapy
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DNA methylation
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Mouse models
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ADHD
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Learning
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Mice
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