A speed–fidelity trade-off determines the mutation rate and virulence of an RNA virus

• William J. Fitzsimmons,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Affiliation Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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• Robert J. Woods,

  Roles Conceptualization, Formal analysis, Investigation, Visualization, Writing – original draft

  Affiliation Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

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• John T. McCrone,

  Roles Data curation, Investigation, Resources, Software

  Affiliation Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States of America

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• Andrew Woodman,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Jamie J. Arnold,

  Roles Formal analysis, Investigation, Methodology, Supervision, Validation

  Affiliation Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Madhumita Yennawar,

  Roles Investigation

  Affiliation Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Richard Evans,

  Roles Data curation, Formal analysis

  Affiliation Department of Epidemiology, University of Michigan, Ann Arbor, Michigan United States of America

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• Craig E. Cameron,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Writing – review & editing

  Affiliation Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Adam S. Lauring

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: alauring@med.umich.edu

  Affiliations Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States of America

  http://orcid.org/0000-0003-2906-8335

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