Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock

Kenneth Allen Dyar; Michaël Jean Hubert; Ashfaq Ali Mir; Stefano Ciciliot; Dominik Lutter; Franziska Greulich; Fabiana Quagliarini; Maximilian Kleinert; Katrin Fischer; Thomas Oliver Eichmann; Lauren Emily Wright; Marcia Ivonne Peña Paz; Alberto Casarin; Vanessa Pertegato; Vanina Romanello; Mattia Albiero; Sara Mazzucco; Rosario Rizzuto; Leonardo Salviati; Gianni Biolo; Bert Blaauw; Stefano Schiaffino; N. Henriette Uhlenhaut

doi:10.1371/journal.pbio.2005886

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Peer-reviewed

Methods and Resources report novel methods, substantial improvements to current methodologies, or informational datasets.

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Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock

Kenneth Allen Dyar ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: kenneth.dyar@helmholtz-muenchen.de (KAD); henriette.uhlenhaut@helmholtz-muenchen.de (NHU)

Affiliations Helmholtz Diabetes Center (HMGU) and German Center for Diabetes Research (DZD), Institute for Diabetes and Obesity (IDO), Munich, Germany, Venetian Institute of Molecular Medicine (VIMM), Padova, Italy
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Michaël Jean Hubert,

Roles Formal analysis, Investigation, Validation, Visualization

Affiliation Helmholtz Diabetes Center (HMGU) and German Center for Diabetes Research (DZD), Institute for Diabetes and Obesity (IDO), Munich, Germany
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Ashfaq Ali Mir,

Roles Data curation, Formal analysis, Software, Visualization

Affiliation Helmholtz Diabetes Center (HMGU) and German Center for Diabetes Research (DZD), Institute for Diabetes and Obesity (IDO), Munich, Germany
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Stefano Ciciliot,

Roles Formal analysis, Investigation, Methodology, Validation

Affiliation Venetian Institute of Molecular Medicine (VIMM), Padova, Italy
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Dominik Lutter,

Roles Data curation, Formal analysis, Investigation, Software, Visualization, Writing – review & editing

Affiliation Helmholtz Diabetes Center (HMGU) and German Center for Diabetes Research (DZD), Institute for Diabetes and Obesity (IDO), Munich, Germany
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Franziska Greulich,

Roles Data curation, Formal analysis, Methodology, Software, Visualization

Affiliation Helmholtz Diabetes Center (HMGU) and German Center for Diabetes Research (DZD), Institute for Diabetes and Obesity (IDO), Munich, Germany
⨯
Fabiana Quagliarini,

Roles Investigation, Methodology

Affiliation Helmholtz Diabetes Center (HMGU) and German Center for Diabetes Research (DZD), Institute for Diabetes and Obesity (IDO), Munich, Germany
⨯
Maximilian Kleinert,

Roles Investigation, Methodology, Resources

Affiliation Helmholtz Diabetes Center (HMGU) and German Center for Diabetes Research (DZD), Institute for Diabetes and Obesity (IDO), Munich, Germany
⨯
Katrin Fischer,

Roles Investigation, Methodology, Visualization

Affiliation Helmholtz Diabetes Center (HMGU) and German Center for Diabetes Research (DZD), Institute for Diabetes and Obesity (IDO), Munich, Germany
⨯
Thomas Oliver Eichmann,

Roles Formal analysis, Investigation, Methodology, Validation

Affiliation Institute of Molecular Biosciences, University of Graz, Graz, Austria
⨯
Lauren Emily Wright,

Roles Formal analysis, Investigation, Methodology, Validation

Affiliation Department of Biomedical Sciences, University of Padova, Padova, Italy
⨯
Marcia Ivonne Peña Paz,

Roles Investigation

Affiliation Venetian Institute of Molecular Medicine (VIMM), Padova, Italy
⨯
Alberto Casarin,

Roles Formal analysis, Investigation, Methodology, Validation

Affiliation Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, and IRP Città della Speranza, Padova, Italy
⨯
Vanessa Pertegato,

Roles Formal analysis, Investigation, Methodology, Validation

Affiliation Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, and IRP Città della Speranza, Padova, Italy
⨯
Vanina Romanello,

Roles Formal analysis, Investigation, Methodology, Resources, Validation

Affiliation Venetian Institute of Molecular Medicine (VIMM), Padova, Italy
⨯
Mattia Albiero,

Roles Investigation, Methodology, Resources

Affiliation Venetian Institute of Molecular Medicine (VIMM), Padova, Italy
⨯
Sara Mazzucco,

Roles Investigation, Methodology, Resources, Validation

Affiliation Clinica Medica, Department of Medical Sciences, University of Trieste, Trieste, Italy
⨯
Rosario Rizzuto,

Roles Methodology, Resources, Supervision

Affiliation Department of Biomedical Sciences, University of Padova, Padova, Italy
⨯
Leonardo Salviati,

Roles Methodology, Resources, Supervision

Affiliation Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, and IRP Città della Speranza, Padova, Italy
⨯
Gianni Biolo,

Roles Methodology, Resources

Affiliation Clinica Medica, Department of Medical Sciences, University of Trieste, Trieste, Italy
⨯
Bert Blaauw,

Roles Conceptualization, Methodology, Resources

Affiliations Venetian Institute of Molecular Medicine (VIMM), Padova, Italy, Department of Biomedical Sciences, University of Padova, Padova, Italy
⨯
Stefano Schiaffino,

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft

Affiliation Venetian Institute of Molecular Medicine (VIMM), Padova, Italy
⨯
[ ... ],
N. Henriette Uhlenhaut

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: kenneth.dyar@helmholtz-muenchen.de (KAD); henriette.uhlenhaut@helmholtz-muenchen.de (NHU)

Affiliations Helmholtz Diabetes Center (HMGU) and German Center for Diabetes Research (DZD), Institute for Diabetes and Obesity (IDO), Munich, Germany, Gene Center, Ludwig-Maximilians-Universitaet (LMU), Munich, Germany

http://orcid.org/0000-0002-4220-4779

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Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock

Kenneth Allen Dyar,
Michaël Jean Hubert,
Ashfaq Ali Mir,
Stefano Ciciliot,
Dominik Lutter,
Franziska Greulich,
Fabiana Quagliarini,
Maximilian Kleinert,
Katrin Fischer,
Thomas Oliver Eichmann

Published: August 10, 2018
https://doi.org/10.1371/journal.pbio.2005886

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Muscle proteins
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Skeletal muscles
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Lipid metabolism
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Muscle protein synthesis
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Gene expression
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Circadian oscillators
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Protein metabolism
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Amino acid metabolism
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