In vitro–transcribed guide RNAs trigger an innate immune response via the RIG-I pathway

• Beeke Wienert,

  Roles Conceptualization, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Innovative Genomics Initiative, University of California, Berkeley, Berkeley, California, United States of America, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America

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• Jiyung Shin,

  Roles Investigation

  Affiliations Innovative Genomics Initiative, University of California, Berkeley, Berkeley, California, United States of America, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America

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• Elena Zelin,

  Roles Conceptualization, Investigation

  Affiliations Innovative Genomics Initiative, University of California, Berkeley, Berkeley, California, United States of America, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America

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• Kathleen Pestal,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America

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• Jacob E. Corn

  Roles Conceptualization, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: jcorn@berkeley.edu

  Affiliations Innovative Genomics Initiative, University of California, Berkeley, Berkeley, California, United States of America, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America

  http://orcid.org/0000-0002-7798-5309

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