Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation

Oswaldo A. Lozoya; Inmaculada Martinez-Reyes; Tianyuan Wang; Dagoberto Grenet; Pierre Bushel; Jianying Li; Navdeep Chandel; Richard P. Woychik; Janine H. Santos

doi:10.1371/journal.pbio.2005707

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Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation

Oswaldo A. Lozoya,

Roles Formal analysis, Investigation, Methodology

Affiliation Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, United States of America
⨯
Inmaculada Martinez-Reyes,

Roles Methodology

Affiliation Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯
Tianyuan Wang,

Roles Formal analysis

Affiliation Integrative Bioinformatics Group, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, United States of America
⨯
Dagoberto Grenet,

Roles Investigation

Affiliation Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, United States of America
⨯
Pierre Bushel,

Roles Formal analysis

Affiliation Biostatistics and Computational Biology Group, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, United States of America
⨯
Jianying Li,

Roles Formal analysis

Affiliation Integrative Bioinformatics Group, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, United States of America
⨯
Navdeep Chandel,

Roles Methodology

Affiliation Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯
Richard P. Woychik ,

Roles Funding acquisition, Writing – review & editing

* E-mail: janine.santos@nih.gov (JHS); rick.woychik@nih.gov (RPW)

Affiliation Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, United States of America
⨯
Janine H. Santos

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: janine.santos@nih.gov (JHS); rick.woychik@nih.gov (RPW)

Affiliation Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, United States of America

http://orcid.org/0000-0001-6384-3070

⨯

Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation

Oswaldo A. Lozoya,
Inmaculada Martinez-Reyes,
Tianyuan Wang,
Dagoberto Grenet,
Pierre Bushel,
Jianying Li,
Navdeep Chandel,
Richard P. Woychik,
Janine H. Santos

Published: April 18, 2018
https://doi.org/10.1371/journal.pbio.2005707

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Mitochondrial DNA
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DNA methylation
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Mitochondria
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Methionine
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Cell metabolism
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Amino acid metabolism
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Gene expression
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Metabolic pathways
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