The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation

• Konstantin Knoblich ,

  Contributed equally to this work with: Konstantin Knoblich, Sara Cruz Migoni, Susan M. Siew

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: Anne.L.Fletcher@monash.edu (AF); Konstantin.Knoblich@monash.edu (KK)

  Affiliations Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, United Kingdom, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia

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• Sara Cruz Migoni ,

  Contributed equally to this work with: Konstantin Knoblich, Sara Cruz Migoni, Susan M. Siew

  Roles Investigation, Validation, Visualization

  Affiliation Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, United Kingdom

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• Susan M. Siew ,

  Contributed equally to this work with: Konstantin Knoblich, Sara Cruz Migoni, Susan M. Siew

  Roles Investigation

  Affiliations Centre for Liver Research, Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, United Kingdom, Liver Unit, University Hospitals Birmingham National Health Service Foundation Trust, Edgbaston, Birmingham, United Kingdom, Department of Gastroenterology and James Fairfax Institute of Paediatric Nutrition, The Children’s Hospital at Westmead, Sydney, Australia

  ⨯
• Elizabeth Jinks,

  Roles Investigation, Validation

  Affiliation Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, United Kingdom

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• Baksho Kaul,

  Roles Investigation, Validation, Visualization

  Affiliation Centre for Liver Research, Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, United Kingdom

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• Hannah C. Jeffery,

  Roles Investigation, Validation, Visualization

  Affiliation Centre for Liver Research, Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, United Kingdom

  ⨯
• Alfie T. Baker,

  Roles Investigation, Validation

  Affiliation Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia

  ⨯
• Muath Suliman,

  Roles Investigation

  Affiliation Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, United Kingdom

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• Katerina Vrzalikova,

  Roles Resources

  Affiliation Institute of Cancer and Genomic Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom

  ⨯
• Hisham Mehenna,

  Roles Resources

  Affiliations Institute of Cancer and Genomic Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom, Institute of Head and Neck Studies and Education, University of Birmingham, Edgbaston, Birmingham, United Kingdom

  ⨯
• Paul G. Murray,

  Roles Resources

  Affiliation Institute of Cancer and Genomic Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom

  ⨯
• Francesca Barone,

  Roles Resources

  Affiliation Institute of Inflammation and Ageing, University of Birmingham, Edgbaston, Birmingham, United Kingdom

  ⨯
• Ye H. Oo,

  Roles Supervision

  Affiliations Centre for Liver Research, Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, United Kingdom, Liver Unit, University Hospitals Birmingham National Health Service Foundation Trust, Edgbaston, Birmingham, United Kingdom, National Institute for Health Research Liver Biomedical Research Unit at University Hospitals Birmingham National Health Service Foundation Trust and the University of Birmingham, Edgbaston, Birmingham, United Kingdom

  ⨯
• Philip N. Newsome,

  Roles Resources, Supervision

  Affiliations Centre for Liver Research, Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, United Kingdom, Liver Unit, University Hospitals Birmingham National Health Service Foundation Trust, Edgbaston, Birmingham, United Kingdom, National Institute for Health Research Liver Biomedical Research Unit at University Hospitals Birmingham National Health Service Foundation Trust and the University of Birmingham, Edgbaston, Birmingham, United Kingdom

  ⨯
• Gideon Hirschfield,

  Roles Resources, Supervision

  Affiliations Centre for Liver Research, Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, United Kingdom, Liver Unit, University Hospitals Birmingham National Health Service Foundation Trust, Edgbaston, Birmingham, United Kingdom, National Institute for Health Research Liver Biomedical Research Unit at University Hospitals Birmingham National Health Service Foundation Trust and the University of Birmingham, Edgbaston, Birmingham, United Kingdom

  ⨯
• Deirdre Kelly,

  Roles Resources

  Affiliation Liver Unit, University Hospitals Birmingham National Health Service Foundation Trust, Edgbaston, Birmingham, United Kingdom

  ⨯
• Steven P. Lee,

  Roles Investigation, Visualization

  Affiliation Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, United Kingdom

  ⨯
• Biju Parekkadan,

  Roles Conceptualization

  Affiliation Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey, United States of America

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• Shannon J. Turley,

  Roles Conceptualization

  Affiliation Department of Cancer Immunology, Genentech, South San Francisco, United States of America

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•  [ ... ],
• Anne L. Fletcher

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: Anne.L.Fletcher@monash.edu (AF); Konstantin.Knoblich@monash.edu (KK)

  Affiliations Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, United Kingdom, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia

  http://orcid.org/0000-0003-1534-1142

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