Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids

• Ewa M. Michalak ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: visvader@wehi.edu.au (JEV); ewa.michalak@petermac.org (EMM)

  Current address: Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

  Affiliations ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia

  http://orcid.org/0000-0002-5772-2122

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• Michael J. G. Milevskiy ,

  Contributed equally to this work with: Michael J. G. Milevskiy, Rachel M. Joyce

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – review & editing

  Affiliations ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia

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• Rachel M. Joyce ,

  Contributed equally to this work with: Michael J. G. Milevskiy, Rachel M. Joyce

  Roles Investigation

  Affiliations ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia

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• Johanna F. Dekkers,

  Roles Investigation, Resources

  Affiliations ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia

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• Paul R. Jamieson,

  Roles Resources

  Affiliations ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia

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• Bhupinder Pal,

  Roles Investigation

  Affiliations ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia

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• Caleb A. Dawson,

  Roles Data curation, Investigation

  Affiliations ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia

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• Yifang Hu,

  Roles Data curation, Investigation

  Affiliation Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

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• Stuart H. Orkin,

  Roles Resources

  Affiliation Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Boston Children’s Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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• Warren S. Alexander,

  Roles Resources

  Affiliations Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia, Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

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• Geoffrey J. Lindeman,

  Roles Funding acquisition, Resources

  Affiliations ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medicine, University of Melbourne, Parkville, Victoria, Australia, Familial Cancer Centre, Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Parkville, Victoria, Australia

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• Gordon K. Smyth,

  Roles Data curation, Methodology

  Affiliations Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, School of Mathematics and Statistics, The University of Melbourne, Parkville, Victoria, Australia

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• Jane E. Visvader

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: visvader@wehi.edu.au (JEV); ewa.michalak@petermac.org (EMM)

  Affiliations ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia

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