Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel

Ákos Nemecz; Haidai Hu; Zaineb Fourati; Catherine Van Renterghem; Marc Delarue; Pierre-Jean Corringer

doi:10.1371/journal.pbio.2004470

Open Access

Peer-reviewed

Research Article

Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel

Ákos Nemecz,

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Unité Récepteurs-Canaux, Unité Mixte de Recherche 3571 du Centre National de la Recherche Scientifique, Institut Pasteur, Paris, France
⨯
Haidai Hu,

Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

Affiliation Unité de Dynamique Structurale des Macromolécules, Unité Mixte de Recherche 3528 du Centre National de la Recherche Scientifique, Institut Pasteur, Paris, France
⨯
Zaineb Fourati,

Roles Data curation, Formal analysis, Investigation, Visualization

Affiliation Unité de Dynamique Structurale des Macromolécules, Unité Mixte de Recherche 3528 du Centre National de la Recherche Scientifique, Institut Pasteur, Paris, France
⨯
Catherine Van Renterghem,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Unité Récepteurs-Canaux, Unité Mixte de Recherche 3571 du Centre National de la Recherche Scientifique, Institut Pasteur, Paris, France
⨯
Marc Delarue,

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – review & editing

Affiliation Unité de Dynamique Structurale des Macromolécules, Unité Mixte de Recherche 3528 du Centre National de la Recherche Scientifique, Institut Pasteur, Paris, France
⨯
Pierre-Jean Corringer

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: pierre-jean.corringer@pasteur.fr

Affiliation Unité Récepteurs-Canaux, Unité Mixte de Recherche 3571 du Centre National de la Recherche Scientifique, Institut Pasteur, Paris, France

http://orcid.org/0000-0002-4770-430X

⨯

Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel

Ákos Nemecz, …
Haidai Hu,
Zaineb Fourati,
Catherine Van Renterghem,
Marc Delarue,
Pierre-Jean Corringer

Published: December 27, 2017
https://doi.org/10.1371/journal.pbio.2004470

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Protons
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Crystal structure
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Ligand-gated ion channels
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Oocytes
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Proton channels
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