Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation

Muhammad S. Alam; Matthias M. Gaida; Subrata Debnath; Harichandra D. Tagad; Lisa M. Miller Jenkins; Ettore Appella; M. Jubayer Rahman; Jonathan D. Ashwell

doi:10.1371/journal.pbio.2004111

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Open Access

Peer-reviewed

Research Article

Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation

Muhammad S. Alam,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliation Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Matthias M. Gaida,

Roles Investigation

Affiliations Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany
⨯
Subrata Debnath,

Roles Investigation

Affiliation Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Harichandra D. Tagad,

Roles Investigation

Affiliation Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Lisa M. Miller Jenkins,

Roles Investigation

Affiliation Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Ettore Appella,

Roles Supervision

Affiliation Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
M. Jubayer Rahman,

Roles Investigation

Affiliation Laboratory of Molecular Immunology at the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, Maryland, United States of America
⨯
Jonathan D. Ashwell

Roles Conceptualization, Formal analysis, Methodology, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: jda@pop.nci.nih.gov

Affiliation Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

http://orcid.org/0000-0002-7386-8738

⨯

Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation

Muhammad S. Alam,
Matthias M. Gaida,
Subrata Debnath,
Harichandra D. Tagad,
Lisa M. Miller Jenkins,
Ettore Appella,
M. Jubayer Rahman,
Jonathan D. Ashwell

Published: January 22, 2018
https://doi.org/10.1371/journal.pbio.2004111

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T cells
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Phosphorylation
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T cell receptors
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TCR signaling cascade
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