Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map

• Ian Smith ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Peyton G. Greenside ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Ted Natoli,

  Roles Data curation, Investigation, Methodology, Software, Visualization

  Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• David L. Lahr,

  Roles Data curation, Methodology, Resources, Software, Validation

  Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• David Wadden,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Itay Tirosh,

  Roles Formal analysis

  Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Rajiv Narayan,

  Roles Data curation, Methodology, Resources, Software

  Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• David E. Root,

  Roles Supervision, Writing – review & editing

  Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Todd R. Golub,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision

  Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

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• Aravind Subramanian ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision

  * E-mail: aravind@broadinstitute.org (AS); jdoench@broadinstitute.org (JGD)

  Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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• John G. Doench

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: aravind@broadinstitute.org (AS); jdoench@broadinstitute.org (JGD)

  Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

  http://orcid.org/0000-0002-3707-9889

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