The Ink4a/Arf locus operates as a regulator of the circadian clock modulating RAS activity

• Rukeia El-Athman ,

  Contributed equally to this work with: Rukeia El-Athman, Nikolai N. Genov, Jeannine Mazuch

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Institute for Theoretical Biology, Germany, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Medical Department of Hematology, Oncology, and Tumor Immunology, and Molecular Cancer Research Center, Germany

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• Nikolai N. Genov ,

  Contributed equally to this work with: Rukeia El-Athman, Nikolai N. Genov, Jeannine Mazuch

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliations Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Institute for Theoretical Biology, Germany, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Medical Department of Hematology, Oncology, and Tumor Immunology, and Molecular Cancer Research Center, Germany

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• Jeannine Mazuch ,

  Contributed equally to this work with: Rukeia El-Athman, Nikolai N. Genov, Jeannine Mazuch

  Roles Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Institute for Theoretical Biology, Germany, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Medical Department of Hematology, Oncology, and Tumor Immunology, and Molecular Cancer Research Center, Germany

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• Kaiyang Zhang,

  Roles Methodology, Writing – review & editing

  Current address: Research Programs Unit, Genome-Scale Biology, Faculty of Medicine, University of Helsinki, Finland

  Affiliation Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Institute for Theoretical Biology, Germany

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• Yong Yu,

  Roles Methodology, Validation, Writing – review & editing

  Affiliation Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

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• Luise Fuhr,

  Roles Methodology, Validation, Writing – review & editing

  Affiliations Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Institute for Theoretical Biology, Germany, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Medical Department of Hematology, Oncology, and Tumor Immunology, and Molecular Cancer Research Center, Germany

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• Mónica Abreu,

  Roles Methodology, Validation, Writing – review & editing

  Affiliations Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Institute for Theoretical Biology, Germany, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Medical Department of Hematology, Oncology, and Tumor Immunology, and Molecular Cancer Research Center, Germany

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• Yin Li,

  Roles Methodology, Validation, Writing – review & editing

  Affiliations Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Institute for Theoretical Biology, Germany, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Medical Department of Hematology, Oncology, and Tumor Immunology, and Molecular Cancer Research Center, Germany

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• Thomas Wallach,

  Roles Methodology, Validation, Writing – review & editing

  Affiliation Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Laboratory of Chronobiology, Berlin, Germany

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• Achim Kramer,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Laboratory of Chronobiology, Berlin, Germany

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• Clemens A. Schmitt,

  Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing

  Affiliations Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Medical Department of Hematology, Oncology, and Tumor Immunology, and Molecular Cancer Research Center, Germany, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

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• Angela Relógio

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: angela.relogio@charite.de

  Affiliations Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Institute for Theoretical Biology, Germany, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Medical Department of Hematology, Oncology, and Tumor Immunology, and Molecular Cancer Research Center, Germany

  http://orcid.org/0000-0002-9165-2439

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