Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number

Dimitris Katsanos; Sneha L. Koneru; Lamia Mestek Boukhibar; Nicola Gritti; Ritobrata Ghose; Peter J. Appleford; Maria Doitsidou; Alison Woollard; Jeroen S. van Zon; Richard J. Poole; Michalis Barkoulas

doi:10.1371/journal.pbio.2002429

Loading metrics

Open Access

Peer-reviewed

Research Article

Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number

Dimitris Katsanos,

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Life Sciences, Imperial College, London, United Kingdom
⨯
Sneha L. Koneru,

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Life Sciences, Imperial College, London, United Kingdom
⨯
Lamia Mestek Boukhibar,

Roles Investigation

Current address: Centre for Translational Omics—GOSgene, Genetics and Genomic Medicine, University College London, Institute of Child Health, London, United Kingdom

Affiliation Department of Life Sciences, Imperial College, London, United Kingdom
⨯
Nicola Gritti,

Roles Formal analysis, Investigation, Methodology

Affiliation Institute for Atomic and Molecular Physics (AMOLF), Amsterdam, The Netherlands
⨯
Ritobrata Ghose,

Roles Investigation, Methodology

Affiliation Department of Life Sciences, Imperial College, London, United Kingdom
⨯
Peter J. Appleford,

Roles Investigation, Methodology, Resources

Affiliation Department of Biochemistry, University of Oxford, Oxford, United Kingdom
⨯
Maria Doitsidou,

Roles Investigation, Resources, Writing – review & editing

Affiliation Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
⨯
Alison Woollard,

Roles Investigation, Resources

Affiliation Department of Biochemistry, University of Oxford, Oxford, United Kingdom
⨯
Jeroen S. van Zon,

Roles Formal analysis, Investigation, Methodology

Affiliation Institute for Atomic and Molecular Physics (AMOLF), Amsterdam, The Netherlands
⨯
Richard J. Poole,

Roles Formal analysis, Investigation, Methodology, Resources, Writing – review & editing

Affiliation Department of Cell and Developmental Biology, University College London, London, United Kingdom
⨯
Michalis Barkoulas

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: m.barkoulas@imperial.ac.uk

Affiliation Department of Life Sciences, Imperial College, London, United Kingdom

http://orcid.org/0000-0003-1974-7668

⨯

Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number

Dimitris Katsanos,
Sneha L. Koneru,
Lamia Mestek Boukhibar,
Nicola Gritti,
Ritobrata Ghose,
Peter J. Appleford,
Maria Doitsidou,
Alison Woollard,
Jeroen S. van Zon,
Richard J. Poole

Published: November 6, 2017
https://doi.org/10.1371/journal.pbio.2002429

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cell cycle and cell division
Is the Subject Area "Cell cycle and cell division" applicable to this article?

Thanks for your feedback.
Phenotypes
Is the Subject Area "Phenotypes" applicable to this article?

Thanks for your feedback.
Larvae
Is the Subject Area "Larvae" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Caenorhabditis elegans
Is the Subject Area "Caenorhabditis elegans" applicable to this article?

Thanks for your feedback.
Green fluorescent protein
Is the Subject Area "Green fluorescent protein" applicable to this article?

Thanks for your feedback.
Cell division analysis
Is the Subject Area "Cell division analysis" applicable to this article?

Thanks for your feedback.
RNA interference
Is the Subject Area "RNA interference" applicable to this article?

Thanks for your feedback.