The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile

• Jesse Lyons ,

  Roles Conceptualization, Data curation, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliations Cancer Research Institute, Beth Israel Deaconess Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

  ⨯
• Phaedra C. Ghazi ,

  Roles Investigation, Methodology, Validation

  ¶‡ These authors share first authorship on this work.

  Affiliation Cancer Research Institute, Beth Israel Deaconess Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Alina Starchenko,

  Roles Investigation

  Affiliations Cancer Research Institute, Beth Israel Deaconess Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

  ⨯
• Alessio Tovaglieri,

  Roles Investigation, Methodology, Validation

  Affiliation Division of Endocrinology, Boston Children’s Hospital, Boston, Massachusetts, United States of America

  ⨯
• Katherine R. Baldwin,

  Roles Investigation, Methodology, Validation

  Affiliations Cancer Research Institute, Beth Israel Deaconess Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Pediatric Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

  ⨯
• Emily J. Poulin,

  Roles Investigation, Methodology, Validation

  Affiliation Cancer Research Institute, Beth Israel Deaconess Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Jessica J. Gierut,

  Roles Investigation, Methodology, Validation

  Affiliation Cancer Research Institute, Beth Israel Deaconess Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Casie Genetti,

  Roles Investigation, Methodology, Validation

  Affiliation Cancer Research Institute, Beth Israel Deaconess Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Vijay Yajnik,

  Roles Conceptualization, Resources

  Affiliation Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

  ⨯
• David T. Breault,

  Roles Conceptualization, Resources, Writing – original draft

  Affiliations Division of Endocrinology, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America, Harvard Stem Cell Institute, Cambridge, Massachusetts, United States of America, Harvard Digestive Disease Center, Boston, Massachusetts, United States of America

  ⨯
• Douglas A. Lauffenburger,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Writing – original draft, Writing – review & editing

  Affiliation Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

  ⨯
• Kevin M. Haigis

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: khaigis@bidmc.harvard.edu

  Affiliations Cancer Research Institute, Beth Israel Deaconess Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Harvard Digestive Disease Center, Boston, Massachusetts, United States of America

  http://orcid.org/0000-0003-1922-4509

  ⨯