Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain

• Nathanael G. Lintner,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Writing – original draft, Writing – review & editing

  Current address: Chemical Biology, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America

  Affiliation Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America

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• Kim F. McClure,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Pfizer Medicinal Chemistry, Cardiovascular, Metabolic and Endocrine Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America

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• Donna Petersen,

  Roles Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Primary Pharmacology Group, Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America

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• Allyn T. Londregan,

  Roles Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Pfizer Medicinal Chemistry, Cardiovascular, Metabolic and Endocrine Disease Research Unit, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America

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• David W. Piotrowski,

  Roles Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Pfizer Medicinal Chemistry, Cardiovascular, Metabolic and Endocrine Disease Research Unit, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America

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• Liuqing Wei,

  Roles Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Pfizer Medicinal Chemistry, Cardiovascular, Metabolic and Endocrine Disease Research Unit, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America

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• Jun Xiao,

  Roles Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Pfizer Medicinal Chemistry, Cardiovascular, Metabolic and Endocrine Disease Research Unit, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America

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• Michael Bolt,

  Roles Conceptualization, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Drug Safety Research & Development, Pfizer Worldwide Research & Development, Andover, Massachusetts, United States of America

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• Paula M. Loria,

  Roles Conceptualization, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Primary Pharmacology Group, Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America

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• Bruce Maguire,

  Roles Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Primary Pharmacology Group, Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America

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• Kieran F. Geoghegan,

  Roles Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Pfizer Medicinal Chemistry, Structural Biology and Biophysics, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America

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• Austin Huang,

  Roles Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Pfizer Medicinal Chemistry, Computational Sciences, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America

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• Tim Rolph,

  Roles Conceptualization, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Cardiovascular, Metabolic and Endocrine Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America

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• Spiros Liras,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Pfizer Medicinal Chemistry, Cardiovascular, Metabolic and Endocrine Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America, Pfizer Medicinal Chemistry, Cardiovascular, Metabolic and Endocrine Disease Research Unit, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America

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• Jennifer A. Doudna,

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliations Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America, QB3 Institute, University of California, Berkeley, Berkeley, California, United States of America, Department of Chemistry, University of California, Berkeley, Berkeley, California, United States of America, Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America, Howard Hughes Medical Institute (HHMI), University of California, Berkeley, Berkeley, California, United States of America

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• Robert G. Dullea ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: robert.dullea@pfizer.com (RGD); jcate@lbl.gov (JHDC)

  Affiliation Cardiovascular, Metabolic and Endocrine Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America

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•  [ ... ],
• Jamie H. D. Cate

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: robert.dullea@pfizer.com (RGD); jcate@lbl.gov (JHDC)

  Affiliations Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America, QB3 Institute, University of California, Berkeley, Berkeley, California, United States of America, Department of Chemistry, University of California, Berkeley, Berkeley, California, United States of America, Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

  http://orcid.org/0000-0001-5965-7902

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