Viral genetic variation accounts for a third of variability in HIV-1 set-point viral load in Europe

• François Blanquart ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  * E-mail: f.blanquart@imperial.ac.uk (FB); christophe.fraser@bdi.ox.ac.uk (CF)

  Affiliation Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom

  http://orcid.org/0000-0003-0591-2466

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• Chris Wymant,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom, Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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• Marion Cornelissen,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands

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• Astrid Gall,

  Roles Investigation, Writing – review & editing

  Current address: Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

  Affiliation Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom

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• Margreet Bakker,

  Roles Data curation, Investigation

  Affiliation Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands

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• Daniela Bezemer,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Stichting HIV Monitoring, Amsterdam, the Netherlands

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• Matthew Hall,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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• Mariska Hillebregt,

  Roles Data curation, Investigation

  Affiliation Stichting HIV Monitoring, Amsterdam, the Netherlands

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• Swee Hoe Ong,

  Roles Investigation

  Affiliation Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom

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• Jan Albert,

  Roles Writing – review & editing

  Affiliations Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden, Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden

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• Norbert Bannert,

  Roles Investigation

  Affiliation Division for HIV and other Retroviruses, Robert Koch Institute, Berlin, Germany

  ⨯
• Jacques Fellay,

  Roles Writing – review & editing

  Affiliations School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland

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• Katrien Fransen,

  Roles Investigation

  Affiliation HIV/STI reference laboratory, WHO collaborating centre, Institute of Tropical Medicine, Department of Clinical Science, Antwerpen, Belgium

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• Annabelle J. Gourlay,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Infection and Population Health, University College London, London, United Kingdom

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• M. Kate Grabowski,

  Roles Investigation

  Affiliation Department of Epidemiology, John Hopkins University, Baltimore, Maryland, United States of America

  ⨯
• Barbara Gunsenheimer-Bartmeyer,

  Roles Investigation

  Affiliation Department of Infectious Disease Epidemiology, Robert Koch-Institute, Berlin, Germany

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• Huldrych F. Günthard,

  Roles Investigation, Writing – review & editing

  Affiliations Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland, Institute of Medical Virology, University of Zurich, Zurich, Switzerland

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• Pia Kivelä,

  Roles Investigation

  Affiliation Department of Infectious Diseases, Helsinki University Hospital, Helsinki, Finland

  ⨯
• Roger Kouyos,

  Roles Investigation, Writing – review & editing

  Affiliations Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland, Institute of Medical Virology, University of Zurich, Zurich, Switzerland

  ⨯
• Oliver Laeyendecker,

  Roles Investigation

  Affiliation Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland, United States of America

  ⨯
• Kirsi Liitsola,

  Roles Investigation

  Affiliation Department of Health Security, National Institute for Health and Welfare, Helsinki, Finland

  ⨯
• Laurence Meyer,

  Roles Investigation, Writing – review & editing

  Affiliation INSERM CESP U1018, Université Paris Sud, Université Paris Saclay, APHP, Service de Santé Publique, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France

  ⨯
• Kholoud Porter,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Infection and Population Health, University College London, London, United Kingdom

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• Matti Ristola,

  Roles Investigation

  Affiliation Department of Health Security, National Institute for Health and Welfare, Helsinki, Finland

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• Ard van Sighem,

  Roles Investigation

  Affiliation Stichting HIV Monitoring, Amsterdam, the Netherlands

  ⨯
• Guido Vanham,

  Roles Investigation

  Affiliation Virology Unit, Immunovirology Research Pole, Biomedical Sciences Department, Institute of Tropical Medicine, Antwerpen, Belgium

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• Ben Berkhout,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands

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• Paul Kellam,

  Roles Conceptualization, Investigation

  Affiliations Kymab Ltd, Cambridge, United Kingdom, Division of Infectious Diseases, Department of Medicine, Imperial College London, London, United Kingdom

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• Peter Reiss,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliations Stichting HIV Monitoring, Amsterdam, the Netherlands, Department of Global Health, Academic Medical Center, Amsterdam, the Netherlands

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• Christophe Fraser ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

  * E-mail: f.blanquart@imperial.ac.uk (FB); christophe.fraser@bdi.ox.ac.uk (CF)

  Affiliations Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom, Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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•  [ ... ],
• BEEHIVE collaboration

  ¶Membership of the BEEHIVE collaboration is provided in the Acknowledgments.

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