Early postnatal exposure to isoflurane causes cognitive deficits and disrupts development of newborn hippocampal neurons via activation of the mTOR pathway

• Eunchai Kang ,

  Contributed equally to this work with: Eunchai Kang, Danye Jiang, Yun Kyoung Ryu

  Roles Investigation, Methodology, Supervision, Writing – original draft

  Affiliations Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• Danye Jiang ,

  Contributed equally to this work with: Eunchai Kang, Danye Jiang, Yun Kyoung Ryu

  Roles Investigation, Writing – original draft

  Affiliation Department of Anesthesiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Yun Kyoung Ryu ,

  Contributed equally to this work with: Eunchai Kang, Danye Jiang, Yun Kyoung Ryu

  Roles Conceptualization, Investigation, Methodology, Supervision

  Affiliation Department of Anesthesiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Sanghee Lim,

  Roles Investigation

  Affiliation Department of Anesthesiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Minhye Kwak,

  Roles Investigation

  Affiliation Department of Anesthesiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Christy D. Gray,

  Roles Investigation, Writing – original draft

  Affiliation Department of Anesthesiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Michael Xu,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Anesthesiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Jun H. Choi ,

  Roles Investigation

  ¶¶Author Jun Choi was unavailable at the time of acceptance for publication to confirm his authorship contributions. On his behalf, all other authors have reported his contributions to the best of their knowledge.

  Affiliation Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• Sue Junn,

  Roles Investigation

  Affiliation Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Jieun Kim,

  Roles Investigation

  Affiliation Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Jing Xu,

  Roles Writing – review & editing

  Affiliation Department of Anesthesiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Michele Schaefer,

  Roles Writing – original draft, Writing – review & editing

  Affiliation Department of Anesthesiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• Roger A. Johns,

  Roles Conceptualization, Resources, Supervision, Writing – review & editing

  Affiliation Department of Anesthesiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• Hongjun Song,

  Roles Conceptualization, Methodology, Resources, Supervision, Writing – review & editing

  Affiliations Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, The Solomon Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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• Guo-Li Ming,

  Roles Conceptualization, Methodology, Resources

  Affiliations Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, The Solomon Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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•  [ ... ],
• C. David Mintz

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: cmintz2@jhmi.edu

  Affiliation Department of Anesthesiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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