Nonlatching positive feedback enables robust bimodality by decoupling expression noise from the mean

• Brandon S. Razooky,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York, United States of America, The Gladstone Institutes (Virology and Immunology), San Francisco, California, United States of America, Biophysics Graduate Group, University of California, San Francisco, San Francisco, California, United Sates of America, Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States of America, Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, Tennessee, United States of America

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• Youfang Cao,

  Roles Investigation, Methodology, Software, Writing – review & editing

  Affiliations Theoretical Biology and Biophysics (T-6), Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America, Center for Nonlinear Studies (CNLS), Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

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• Maike M. K. Hansen,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation The Gladstone Institutes (Virology and Immunology), San Francisco, California, United States of America

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• Alan S. Perelson,

  Roles Methodology, Resources, Writing – review & editing

  Affiliation Theoretical Biology and Biophysics (T-6), Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

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• Michael L. Simpson ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: simpsonml1@ornl.gov (MLS); leor.weinberger@gladstone.ucsf.edu (LSW)

  Affiliations Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States of America, Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee, Knoxville, Tennessee, United States of America

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• Leor S. Weinberger

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: simpsonml1@ornl.gov (MLS); leor.weinberger@gladstone.ucsf.edu (LSW)

  Affiliations The Gladstone Institutes (Virology and Immunology), San Francisco, California, United States of America, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America, QB3: California Institute of Quantitative Biosciences, University of California, San Francisco, San Francisco, California, United States of America, Department of Pharmaceutical Chemistry University of California, San Francisco, San Francisco, California, United States of America

  http://orcid.org/0000-0002-9987-6357

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