STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling Pathways

Johnathan Ho; Christin Pelzel; Andreas Begitt; Maureen Mee; Hany M. Elsheikha; David J. Scott; Uwe Vinkemeier

doi:10.1371/journal.pbio.2000117

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Open Access

Peer-reviewed

Research Article

STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling Pathways

Johnathan Ho,

Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation School of Life Sciences, Queen’s Medical Centre, University of Nottingham, Nottingham, United Kingdom
⨯
Christin Pelzel,

Roles Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

Affiliation School of Life Sciences, Queen’s Medical Centre, University of Nottingham, Nottingham, United Kingdom
⨯
Andreas Begitt,

Roles Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

Affiliation School of Life Sciences, Queen’s Medical Centre, University of Nottingham, Nottingham, United Kingdom
⨯
Maureen Mee,

Roles Investigation, Validation, Visualization

Affiliation School of Life Sciences, Queen’s Medical Centre, University of Nottingham, Nottingham, United Kingdom
⨯
Hany M. Elsheikha,

Roles Investigation, Resources, Supervision, Validation, Writing – review & editing

Affiliation School of Veterinary Medicine and Science, University of Nottingham, Loughborough, United Kingdom
⨯
David J. Scott,

Roles Formal analysis, Investigation, Resources, Supervision, Validation, Visualization, Writing – review & editing

Affiliations ISIS Spallation Neutron and Muon Source, Rutherford Appleton Laboratory, Didcot, United Kingdom, Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, United Kingdom, School of Biosciences, University of Nottingham, Nottingham, United Kingdom
⨯
Uwe Vinkemeier

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: uwe.vinkemeier@nottingham.ac.uk

Affiliation School of Life Sciences, Queen’s Medical Centre, University of Nottingham, Nottingham, United Kingdom
⨯

STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling Pathways

Johnathan Ho,
Christin Pelzel,
Andreas Begitt,
Maureen Mee,
Hany M. Elsheikha,
David J. Scott,
Uwe Vinkemeier

Published: October 25, 2016
https://doi.org/10.1371/journal.pbio.2000117

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Macrophages
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STAT signaling
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Cytokines
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STAT proteins
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