Distribution of Misfolded Prion Protein Seeding Activity Alone Does Not Predict Regions of Neurodegeneration

• James Alibhai,

  Affiliation The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom

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• Richard A. Blanco,

  Affiliation The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom

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• Marcelo A. Barria,

  Affiliation The National CJD Research and Surveillance Unit, Centre for Clinical Brain Sciences, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom

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• Pedro Piccardo,

  Affiliation The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom

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• Byron Caughey,

  Affiliation Laboratory of Persistent Viral Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of America

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• V. Hugh Perry,

  Affiliation Centre for Biological Sciences, University of Southampton, Southampton, United Kingdom

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• Tom C. Freeman ,

  ¶‡ These authors are joint senior authors on this work.

  Affiliation The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom

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• Jean C. Manson

  * E-mail: jean.manson@roslin.ed.ac.uk

  ¶‡ These authors are joint senior authors on this work.

  Affiliation The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom

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