Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation

Xin Sun; Kai Fu; Andrea Hodgson; Eric M. Wier; Matthew G. Wen; Olena Kamenyeva; Xue Xia; Lily Y. Koo; Fengyi Wan

doi:10.1371/journal.pbio.1002543

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Open Access

Peer-reviewed

Research Article

Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation

Xin Sun ,

Contributed equally to this work with: Xin Sun, Kai Fu

Affiliation Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
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Kai Fu ,

Contributed equally to this work with: Xin Sun, Kai Fu

Affiliation Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
⨯
Andrea Hodgson,

Affiliation Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
⨯
Eric M. Wier,

Affiliation Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
⨯
Matthew G. Wen,

Affiliation Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
⨯
Olena Kamenyeva,

Affiliation Biological Imaging Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Xue Xia,

Affiliation Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
⨯
Lily Y. Koo,

Affiliation Biological Imaging Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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Fengyi Wan

* E-mail: fwan1@jhu.edu

Affiliations Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland, United States of America

http://orcid.org/0000-0001-9216-9767

⨯

Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation

Xin Sun,
Kai Fu,
Andrea Hodgson,
Eric M. Wier,
Matthew G. Wen,
Olena Kamenyeva,
Xue Xia,
Lily Y. Koo,
Fengyi Wan

Published: September 16, 2016
https://doi.org/10.1371/journal.pbio.1002543

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DNA damage
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DNA repair
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Immunoprecipitation
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Small interfering RNA
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Thymocytes
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Recombinant proteins
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Transfection
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