Angiogenic Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic Angiogenesis for Heart Disease

Qiulun Lu; Yufeng Yao; Zhenkun Hu; Changqing Hu; Qixue Song; Jian Ye; Chengqi Xu; Annabel Z. Wang; Qiuyun Chen; Qing Kenneth Wang

doi:10.1371/journal.pbio.1002529

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Open Access

Peer-reviewed

Research Article

Angiogenic Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic Angiogenesis for Heart Disease

Qiulun Lu ,

Contributed equally to this work with: Qiulun Lu, Yufeng Yao

Affiliation Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, P. R. China
⨯
Yufeng Yao ,

Contributed equally to this work with: Qiulun Lu, Yufeng Yao

Affiliation Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, P. R. China
⨯
Zhenkun Hu,

Affiliation Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, P. R. China
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Changqing Hu,

Affiliation Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, P. R. China
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Qixue Song,

Affiliation Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, P. R. China
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Jian Ye,

Affiliation Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, P. R. China
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Chengqi Xu,

Affiliation Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, P. R. China
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Annabel Z. Wang,

Affiliation Duke University, Durham, North Carolina, United States of America
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Qiuyun Chen,

Affiliations Center for Cardiovascular Genetics, Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

http://orcid.org/0000-0002-6565-9805

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Qing Kenneth Wang

* E-mail: qkwang@hust.edu.cn; wangq2@ccf.org

Affiliations Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, P. R. China, Center for Cardiovascular Genetics, Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯

Angiogenic Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic Angiogenesis for Heart Disease

Qiulun Lu,
Yufeng Yao,
Zhenkun Hu,
Changqing Hu,
Qixue Song,
Jian Ye,
Chengqi Xu,
Annabel Z. Wang,
Qiuyun Chen,
Qing Kenneth Wang

Published: August 11, 2016
https://doi.org/10.1371/journal.pbio.1002529

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